RAB27B and SEC11A

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		RAB27B	SEC11A
Description		RAB27B, member RAS oncogene family	SEC11 homolog A, signal peptidase complex subunit
Image			No pdb structure
GO Annotations	Cellular Component	Late Endosome Golgi Stack Plasma Membrane Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Platelet Dense Granule Membrane Multivesicular Body Membrane Melanosome Zymogen Granule Membrane Extracellular Exosome Anchored Component Of Synaptic Vesicle Membrane Axon Cytoplasm	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity
	Biological Process	Platelet Degranulation Melanosome Transport Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Multivesicular Body Sorting Pathway Anterograde Axonal Protein Transport	Signal Peptide Processing
Pathways		Platelet degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases
GWAS		Adult body size ( 32376654) Allergic disease (asthma, hay fever or eczema) ( 29083406) Body mass index ( 28892062) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143) Depression ( 29700475) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Response to ketamine in bipolar disorder or major depression (antidepressant effects) ( 30552317) Schizophrenia ( 29483656)
Interacting Genes		11 interacting genes: DHPS GORASP2 MLPH MYRIP RPH3A RPH3AL SYTL1 SYTL2 SYTL4 SYTL5 UNC13D	5 interacting genes: ADAM33 BCHE CSNK2B NUPR1 SLC35F6
Entrez ID		5874	23478
HPRD ID		04846	07503
Ensembl ID		ENSG00000041353	ENSG00000140612
Uniprot IDs		O00194	A0A024RC78 H0YKT4 P67812
PDB IDs		2F7S
Enriched GO Terms of Interacting Partners?
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