ENOPH1 and RAB7A

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		ENOPH1	RAB7A
Description		enolase-phosphatase 1	RAB7A, member RAS oncogene family
Image
GO Annotations	Cellular Component	Nucleus Cytosol	Autophagosome Membrane Lysosome Lysosomal Membrane Late Endosome Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Retromer Complex Late Endosome Membrane Extrinsic Component Of Lysosome Membrane Melanosome Membrane Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Protein Binding 2,3-diketo-5-methylthiopentyl-1-phosphate Enolase Activity 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate Phosphatase Activity Acireductone Synthase Activity	GTPase Activity Protein Binding GTP Binding GDP Binding Retromer Complex Binding
	Biological Process	Dephosphorylation L-methionine Salvage From S-adenosylmethionine L-methionine Salvage From Methylthioadenosine	Autophagosome Assembly Protein Targeting To Lysosome Endocytosis Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Protein Transport Lipid Catabolic Process Viral Release From Host Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Protein To Membrane Docking Retrograde Transport, Endosome To Golgi Neutrophil Degranulation Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Positive Regulation Of Viral Process Lipophagy Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Endosome To Plasma Membrane Protein Transport Multi-organism Intercellular Transport Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Negative Regulation Of Intralumenal Vesicle Formation
Pathways		Methionine salvage pathway	MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Suppression of autophagy
Drugs		2-OXOHEPTYLPHOSPHONIC ACID	Guanosine-5'-Diphosphate
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			Body fat mass ( 28552196) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)
Interacting Genes		6 interacting genes: ERBB3 RAB10 RNF41 RPS27 TSC22D2 ZNF280A	27 interacting genes: CHM KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B PRKN RAB13 RAB17 RAB22A RAB4A RAB4B RAB6A RABAC1 RABGGTB RILP RNF115 SLC2A4 SNX3 TP53 UCHL5 VPS11 VPS16 VPS18 VPS26A VPS29 VPS39 VPS41
Entrez ID		58478	7879
HPRD ID		17467	03805
Ensembl ID		ENSG00000145293	ENSG00000075785
Uniprot IDs		D6RA00 Q9UHY7	A0A158RFU6 P51149
PDB IDs		1YNS 1ZS9	1T91 1YHN 3LAW 6IYB 6WCW
Enriched GO Terms of Interacting Partners?
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