PYGL and IDH2

Data Source:
BioGRID (two hybrid)

		PYGL	IDH2
Description		glycogen phosphorylase L	isocitrate dehydrogenase (NADP(+)) 2
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Mitochondrion Mitochondrial Matrix Peroxisome Cytosol Extracellular Exosome
	Molecular Function	Purine Nucleobase Binding Protein Binding ATP Binding Glucose Binding Drug Binding Glycogen Phosphorylase Activity AMP Binding Vitamin Binding Pyridoxal Phosphate Binding Bile Acid Binding Identical Protein Binding Linear Malto-oligosaccharide Phosphorylase Activity SHG Alpha-glucan Phosphorylase Activity	Magnesium Ion Binding Isocitrate Dehydrogenase (NADP+) Activity NAD Binding
	Biological Process	Glycogen Metabolic Process Glycogen Catabolic Process 5-phosphoribose 1-diphosphate Biosynthetic Process Response To Bacterium Glucose Homeostasis Neutrophil Degranulation Necroptotic Process	Carbohydrate Metabolic Process Glyoxylate Cycle Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process NADP Metabolic Process NADP Biosynthetic Process Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Glial Cell Migration Negative Regulation Of Matrix Metallopeptidase Secretion
Pathways		Neutrophil degranulation Glycogen breakdown (glycogenolysis)	Transcriptional activation of mitochondrial biogenesis Citric acid cycle (TCA cycle)
Drugs			Isocitric Acid Enasidenib
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Acute lymphoblastic leukemia (childhood) ( 23007406) Blood protein levels ( 30072576 29875488) Psychosis (atypical) ( 24132900)	Cerebrospinal fluid clusterin levels ( 26545630) Pulse pressure ( 27841878 30578418) Urate levels ( 31578528)
Interacting Genes		6 interacting genes: BAG1 HSD17B10 HSD3B7 IDH2 PYGB PYGM	3 interacting genes: FBXO7 PYGL SLC2A4
Entrez ID		5836	3418
HPRD ID		01987	00973
Ensembl ID		ENSG00000100504	ENSG00000182054
Uniprot IDs		P06737	B4DSZ6 P48735
PDB IDs		1EM6 1EXV 1FA9 1FC0 1L5Q 1L5R 1L5S 1L7X 1XOI 2ATI 2QLL 2ZB2 3CEH 3CEJ 3CEM 3DD1 3DDS 3DDW	4JA8 5GIS 5I95 5I96 5SVN 5SVO 6ADI 6VFZ
Enriched GO Terms of Interacting Partners?
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