PYCR1 and TNPO2

Data Source:
BioGRID (two hybrid)

		PYCR1	TNPO2
Description		pyrroline-5-carboxylate reductase 1	transportin 2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleus Cytoplasm
	Molecular Function	Pyrroline-5-carboxylate Reductase Activity Protein Binding Identical Protein Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Proline Biosynthetic Process Cellular Amino Acid Biosynthetic Process Cellular Response To Oxidative Stress Regulation Of Mitochondrial Membrane Potential L-proline Biosynthetic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death	Protein Import Into Nucleus
Pathways		Glutamate and glutamine metabolism
Drugs		NADH Proline
Diseases		Geroderma osteodysplasticum
GWAS			Diffuse large B-cell lymphoma or multiple sclerosis ( 31407831)
Interacting Genes		6 interacting genes: BNIPL CDK2AP2 HNRNPD NUDT21 SIRT3 TNPO2	52 interacting genes: A1CF APIP BEND7 BIRC7 BIRC8 BLMH C12orf40 C1orf94 CAMK2B CAMK2D CAMK2G CCDC158 CRYAB CTAG1A CTAG1B ELAVL1 EXOC5 FH FTO FUCA2 GCH1 GSC2 KLHL2 KLHL20 KLHL3 KRT75 KRTAP8-1 NME1 NUP98 NXF1 OTX2 PACSIN3 PDLIM7 PIK3CD PINX1 PNMA5 POU6F2 PRMT8 PYCR1 RAN RBM45 RPL4 RPRD1B SERTAD3 SF1 TBX2 TCL1B TERF1 THAP6 TRIM8 ZBTB32 ZC2HC1C
Entrez ID		5831	30000
HPRD ID		01528	04301
Ensembl ID		ENSG00000183010	ENSG00000105576
Uniprot IDs		A0A024R8U9 E2QRB3 J3QL32 P32322 Q8TBX0	A0A024R7F7 O14787 Q05D48 Q4LE60
PDB IDs		2GER 2GR9 2GRA 2IZZ 5UAT 5UAU 5UAV 5UAW 5UAX 6XOZ 6XP0 6XP1 6XP2 6XP3
Enriched GO Terms of Interacting Partners?
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