PWP2 and TOM1L1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PWP2	TOM1L1
Description		PWP2 small subunit processome component	target of myb1 like 1 membrane trafficking protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Small-subunit Processome Pwp2p-containing Subcomplex Of 90S Preribosome	Cytoplasm Lysosome Endosome Golgi Stack Cytosol Endosome Membrane Membrane Extracellular Exosome
	Molecular Function	RNA Binding	Protein Binding SH3 Domain Binding Protein Kinase Binding Clathrin Binding Protein Kinase Activator Activity Ubiquitin Binding
	Biological Process	Ribosomal Small Subunit Assembly Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing	Intracellular Protein Transport Signal Transduction Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Mitotic Nuclear Division Regulation Of DNA Biosynthetic Process
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS			Carotid intima media thickness x smoking interaction ( 32117412) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Urinary albumin-to-creatinine ratio ( 32600054)
Interacting Genes		4 interacting genes: DCAF7 MAPT MTDH TOM1L1	29 interacting genes: AMFR CCDC47 CELF1 COPS7A CWF19L1 DNAJB13 FYN GLUD2 GRB2 GSN HGS HNRNPH1 MAP3K3 NDC80 NOMO1 PDPN PELP1 PHYH PIK3R1 PWP2 RAB18 TASOR TOLLIP TSG101 TUBA1B UBC UBXN4 VAV2 VCP
Entrez ID		5822	10040
HPRD ID		03279	05266
Ensembl ID		ENSG00000241945	ENSG00000141198
Uniprot IDs		Q15269	O75674 Q8NI65
PDB IDs			3RRU
Enriched GO Terms of Interacting Partners?
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