PTPRF and ZMPSTE24

Data Source:
BioGRID (biochemical)

		PTPRF	ZMPSTE24
Description		protein tyrosine phosphatase receptor type F	zinc metallopeptidase STE24
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Neuronal Cell Body Extracellular Exosome	Nuclear Inner Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane Protein-containing Complex Extracellular Exosome
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Heparin Binding Chondroitin Sulfate Proteoglycan Binding Protein-containing Complex Binding Cell Adhesion Molecule Binding	Double-stranded DNA Binding Metalloendopeptidase Activity Protein Binding Metalloexopeptidase Activity Metal Ion Binding
	Biological Process	Protein Dephosphorylation Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Cell Migration Neuron Projection Regeneration Peptidyl-tyrosine Dephosphorylation Regulation Of Axon Regeneration Synaptic Membrane Adhesion Negative Regulation Of Receptor Binding	Liver Development Hair Follicle Development Heart Morphogenesis Ventricular Cardiac Muscle Tissue Development Cardiac Ventricle Development Growth Plate Cartilage Development DNA Repair Proteolysis Inflammatory Cell Apoptotic Process Nuclear Envelope Organization Adult Walking Behavior Determination Of Adult Lifespan Regulation Of Cell Shape Regulation Of Autophagy Regulation Of Glucose Metabolic Process Regulation Of Lipid Metabolic Process Bone Mineralization Prenylated Protein Catabolic Process Regulation Of Bone Mineralization Regulation Of TOR Signaling Regulation Of Hormone Metabolic Process Multicellular Organism Growth Regulation Of Multicellular Organism Growth Maintenance Of RDNA Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Histone H2B-K5 Acetylation Hypomethylation Of CpG Island Cellular Lipid Metabolic Process Regulation Of Fibroblast Proliferation Thymus Development Cardiac Muscle Fiber Development Regulation Of Defense Response To Virus Neuromuscular Process Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Kidney Morphogenesis Cardiac Conduction CAMKK-AMPK Signaling Cascade Regulation Of Stress-activated Protein Kinase Signaling Cascade Cellular Response To Gamma Radiation CAAX-box Protein Processing Response To DNA Damage Checkpoint Signaling Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Calcium Ion Import Into Sarcoplasmic Reticulum Histone H2A Phosphorylation Regulation Of Histone H4-K16 Acetylation Regulation Of Termination Of RNA Polymerase I Transcription Regulation Of Cellular Senescence
Pathways		Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
Drugs
Diseases			Restrictive dermopathy Mandibuloacral dysplasia
GWAS		Adventurousness ( 30643258) Amyotrophic lateral sclerosis (age of onset) ( 22959728) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention deficit hyperactivity disorder ( 30478444) Attention deficit hyperactivity disorder or cannabis use ( 30610198) Autism spectrum disorder or schizophrenia ( 28540026) Coffee consumption ( 31046077) Cognitive ability (MTAG) ( 29186694) Educational attainment ( 27046643) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Household income (MTAG) ( 31844048) Intake of total sugars ( 31005972) Intelligence (MTAG) ( 29326435) Mean reticulocyte volume ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656 30285260) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Stroke ( 29531354) Urate levels ( 31578528)
Interacting Genes		59 interacting genes: ACAN ACAT1 ACTB ARHGEF11 ARHGEF12 ARHGEF2 ATP5F1A BCAR1 CAV1 CBR1 CDH1 CREBBP CTNNB1 DEPDC1B DIAPH1 EEF1A1 EEF1G FRS2 FYN GALNT1 GAPDH GPC4 HSP90AA1 HSPA1A HSPA1L HSPA5 HSPA8 HSPA9 INSR IRS1 IRS2 JUP LACTB LCK LDHA LDHB NCAN NID1 PPFIA1 PPFIA2 PPFIA3 PRPF40A PTPRA PTPRD PTPRZ1 RAP1GDS1 RET RHOA ROCK2 SEMG1 SEMG2 SEPTIN9 SKIL SOWAHC TRIO TUBA1B TUBB4B VCAN ZNF512B
Entrez ID		5792	10269
HPRD ID		01552	07349
Ensembl ID		ENSG00000142949	ENSG00000084073
Uniprot IDs		G1UI20 P10586	O75844
PDB IDs		1LAR 2DJU 2DN7 2EDX 2EDY 2YD5 2YD8 4N5U 6KR4 6TPT 6TPU 6TPV 6TPW	2YPT 4AW6 5SYT 6BH8
Enriched GO Terms of Interacting Partners?
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