ANKRA2 and PDE3B

Data Source:
BioGRID (unspecified method)

		ANKRA2	PDE3B
Description		ankyrin repeat family A member 2	phosphodiesterase 3B
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GO Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Membrane Protein-containing Complex 3M Complex	Endoplasmic Reticulum Golgi Apparatus Cytosol Membrane Integral Component Of Membrane Guanyl-nucleotide Exchange Factor Complex
	Molecular Function	Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding Low-density Lipoprotein Particle Receptor Binding	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity CGMP-inhibited Cyclic-nucleotide Phosphodiesterase Activity Protein Binding Protein Kinase B Binding Metal Ion Binding
	Biological Process	Regulation Of Gene Expression Regulation Of Protein-containing Complex Assembly	Angiogenesis Negative Regulation Of Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Angiogenesis Cellular Response To Insulin Stimulus Negative Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Lipid Catabolic Process
Pathways			PDE3B signalling PDE3B signalling G alpha (s) signalling events
Drugs			Caffeine Caffeine Amrinone 6-(4-{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-yl]amino}phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one Hg9a-9, Nonanoyl-N-Hydroxyethylglucamide 3-isobutyl-1-methyl-7H-xanthine Trapidil
Diseases
GWAS		Monobrow thickness ( 26926045)	Adiponectin levels ( 31178129) Bipolar disorder ( 31043756) HDL cholesterol ( 30275531) High density lipoprotein cholesterol levels ( 29083408) High light scatter reticulocyte count ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum 25-Hydroxyvitamin D levels ( 31841498) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 30297969) Vitamin D levels ( 25208829) Waist-to-hip ratio adjusted for body mass index ( 28430825)
Interacting Genes		13 interacting genes: ABL1 APP CDKN2A HDAC4 HDAC5 HDAC9 LRP2 MPL NEK6 PDE3B RFX7 SAMD4A TSHZ3	7 interacting genes: AKT1 ANKRA2 HPGDS LNX1 PRKACA YWHAB YWHAQ
Entrez ID		57763	5140
HPRD ID		12044	03626
Ensembl ID		ENSG00000164331	ENSG00000152270
Uniprot IDs		A0A024RAN7 Q9H9E1	A7E2E5 Q13370
PDB IDs		3SO8 3V2O 3V2X 3V31 4LG6 4QQI	1SO2 1SOJ
Enriched GO Terms of Interacting Partners?
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