PDE3B and HPGDS

Data Source:
BioGRID (two hybrid)

		PDE3B	HPGDS
Description		phosphodiesterase 3B	hematopoietic prostaglandin D synthase
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GO Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Cytosol Membrane Integral Component Of Membrane Guanyl-nucleotide Exchange Factor Complex	Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity CGMP-inhibited Cyclic-nucleotide Phosphodiesterase Activity Protein Binding Protein Kinase B Binding Metal Ion Binding	Magnesium Ion Binding Glutathione Transferase Activity Prostaglandin-D Synthase Activity Calcium Ion Binding Protein Binding Protein Homodimerization Activity
	Biological Process	Angiogenesis Negative Regulation Of Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Angiogenesis Cellular Response To Insulin Stimulus Negative Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Lipid Catabolic Process	Prostaglandin Metabolic Process Glutathione Metabolic Process Signal Transduction Locomotory Behavior Cyclooxygenase Pathway Glutathione Derivative Biosynthetic Process
Pathways		PDE3B signalling PDE3B signalling G alpha (s) signalling events	Glutathione conjugation Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs		Caffeine Caffeine Amrinone 6-(4-{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-yl]amino}phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one Hg9a-9, Nonanoyl-N-Hydroxyethylglucamide 3-isobutyl-1-methyl-7H-xanthine Trapidil	Glutathione Tretinoin 2-(2f-Benzothiazolyl)-5-Styryl-3-(4f-Phthalhydrazidyl)Tetrazolium Chloride Glutathione disulfide 3-phenyl-5-(1H-pyrazol-3-yl)isoxazole PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE Tranilast 4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid 4-(BENZHYDRYLOXY)-1-[3-(1H-TETRAAZOL-5-YL)PROPYL]PIPERIDINE Nocodazole 3-(4-nitrophenyl)-1H-pyrazole 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
Diseases
GWAS		Adiponectin levels ( 31178129) Bipolar disorder ( 31043756) HDL cholesterol ( 30275531) High density lipoprotein cholesterol levels ( 29083408) High light scatter reticulocyte count ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum 25-Hydroxyvitamin D levels ( 31841498) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 30297969) Vitamin D levels ( 25208829) Waist-to-hip ratio adjusted for body mass index ( 28430825)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Blood protein levels ( 30072576 29875488) Testicular germ cell tumor ( 28604728 28604732 23666239)
Interacting Genes		7 interacting genes: AKT1 ANKRA2 HPGDS LNX1 PRKACA YWHAB YWHAQ	7 interacting genes: ABHD17A ARRDC3 C14orf39 HK3 LIF MELTF PDE3B
Entrez ID		5140	27306
HPRD ID		03626	04001
Ensembl ID		ENSG00000152270	ENSG00000163106
Uniprot IDs		A7E2E5 Q13370	A0A384P5J0 O60760
PDB IDs		1SO2 1SOJ	1IYH 1IYI 1V40 2CVD 2VCQ 2VCW 2VCX 2VCZ 2VD0 2VD1 3EE2 3KXO 3VI5 3VI7 4EC0 4EDY 4EDZ 4EE0 5AIS 5AIV 5AIX 5YWE 5YWX 5YX1 6N4E 6W58 6W8H
Enriched GO Terms of Interacting Partners?
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