PTPN4 and MAPK12

Data Source:
BioGRID (pull down)

		PTPN4	MAPK12
Description		protein tyrosine phosphatase non-receptor type 4	mitogen-activated protein kinase 12
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Cellular Response To Cytokine Stimulus	MAPK Cascade DNA Damage Induced Protein Phosphorylation Cell Cycle Arrest Signal Transduction Muscle Organ Development Positive Regulation Of Peptidase Activity Peptidyl-serine Phosphorylation Intracellular Signal Transduction Myoblast Differentiation Positive Regulation Of Muscle Cell Differentiation
Pathways		Toll Like Receptor 4 (TLR4) Cascade Interleukin-37 signaling MECP2 regulates neuronal receptors and channels	NOD1/2 Signaling Pathway p38MAPK events Activation of PPARGC1A (PGC-1alpha) by phosphorylation DSCAM interactions VEGFA-VEGFR2 Pathway Myogenesis Myogenesis Negative regulation of MAPK pathway
Drugs		Alendronic acid	Minocycline Phosphonothreonine Phosphoaminophosphonic Acid-Adenylate Ester KC706 CEP-1347
Diseases
GWAS		Lymphocyte counts ( 32888494) Monocyte count ( 32888494)	Acne (severe) ( 24927181) Diverticular disease ( 30177863) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		12 interacting genes: ATRX CRK EEF1A1 EEF1G GRID2 GRIN2A KAT5 LPL MAPK12 PRSS1 TK1 ZZEF1	29 interacting genes: DLG1 DLG2 DLG3 DLG4 DUSP1 EEF2K ERBIN GRB2 GTF2I HTRA2 MAP2K3 MAP2K4 MAP2K6 MAPKAPK5 MAPT MBP PATJ PDGFRL PKN1 PTPN3 PTPN4 RCSD1 RGS3 SH3BP5 SIAH1 SNTA1 SNTB1 SRPK1 TERF1
Entrez ID		5775	6300
HPRD ID		01471	03868
Ensembl ID		ENSG00000088179	ENSG00000188130
Uniprot IDs		P29074	P53778 Q6N076
PDB IDs		2CS5 2I75 2VPH 3NFK 3NFL 5EYZ 5EZ0	1CM8 4QUM 6UNA
Enriched GO Terms of Interacting Partners?
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