PTPN4 and GRID2

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid, in vivo)

		PTPN4	GRID2
Description		protein tyrosine phosphatase non-receptor type 4	glutamate ionotropic receptor delta type subunit 2
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Ionotropic Glutamate Receptor Complex Dendritic Spine Synapse Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding	Ionotropic Glutamate Receptor Activity Protein Binding Glutamate Receptor Activity Ligand-gated Ion Channel Activity PDZ Domain Binding Signaling Receptor Activity Scaffold Protein Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Cellular Response To Cytokine Stimulus	Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Glutamate Receptor Signaling Pathway Regulation Of Neuron Projection Development Cerebellar Granule Cell Differentiation Ion Transmembrane Transport Cellular Protein Localization Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Neuron Apoptotic Process Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synapse Assembly Excitatory Postsynaptic Potential Prepulse Inhibition Regulation Of Postsynaptic Density Assembly Positive Regulation Of Long-term Synaptic Depression Excitatory Synapse Assembly
Pathways		Toll Like Receptor 4 (TLR4) Cascade Interleukin-37 signaling MECP2 regulates neuronal receptors and channels
Drugs		Alendronic acid
Diseases
GWAS		Lymphocyte counts ( 32888494) Monocyte count ( 32888494)	Coffee consumption ( 31046077) Intelligence (MTAG) ( 29326435) Manganese levels ( 26025379) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 30456828) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		12 interacting genes: ATRX CRK EEF1A1 EEF1G GRID2 GRIN2A KAT5 LPL MAPK12 PRSS1 TK1 ZZEF1	10 interacting genes: AP4M1 DLG2 EML1 GOPC GRIA1 GRID2IP GRIK2 GRIK5 MAGI2 PTPN4
Entrez ID		5775	2895
HPRD ID		01471	06781
Ensembl ID		ENSG00000088179	ENSG00000152208
Uniprot IDs		P29074	O43424
PDB IDs		2CS5 2I75 2VPH 3NFK 3NFL 5EYZ 5EZ0	5KC8 5KCA
Enriched GO Terms of Interacting Partners?
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