ALS2 and PPIL3

Data Source:
BioGRID (biochemical)

		ALS2	PPIL3
Description		alsin Rho guanine nucleotide exchange factor ALS2	peptidylprolyl isomerase like 3
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Early Endosome Centrosome Cytosol Lamellipodium Dendrite Growth Cone Vesicle Protein-containing Complex	Catalytic Step 2 Spliceosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding
	Biological Process	Endosome Organization Lysosomal Transport Positive Regulation Of Rac Protein Signal Transduction Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Neuron Projection Morphogenesis Regulation Of Endosome Size Protein Homooligomerization Positive Regulation Of Protein Serine/threonine Kinase Activity	MRNA Splicing, Via Spliceosome Protein Peptidyl-prolyl Isomerization Protein Folding
Pathways		RAB GEFs exchange GTP for GDP on RABs	mRNA Splicing - Major Pathway
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Juvenile primary lateral sclerosis
GWAS		Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Perceived intensity of sweet substances ( 31005972)	Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)
Interacting Genes		1 interacting genes: YWHAB	6 interacting genes: CENATAC PCBP1 SHARPIN SLU7 TAB2 TAB3
Entrez ID		57679	53938
HPRD ID		05893	15163
Ensembl ID		ENSG00000003393	ENSG00000240344
Uniprot IDs		A8K4R4 Q96Q42	A0A024R3V4 A0A0S2Z5A8 Q9H2H8
PDB IDs			1XYH 2OJU 2OK3
Enriched GO Terms of Interacting Partners?
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