PPIL3 and SHARPIN

Data Source:
BioGRID (pull down)

		PPIL3	SHARPIN
Description		peptidylprolyl isomerase like 3	SHANK associated RH domain interactor
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GO Annotations	Cellular Component	Catalytic Step 2 Spliceosome	Ubiquitin Ligase Complex Cytosol Postsynaptic Density Dendrite LUBAC Complex
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome Protein Peptidyl-prolyl Isomerization Protein Folding	Mitochondrion Organization I-kappaB Kinase/NF-kappaB Signaling Brain Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptotic Nuclear Changes Keratinization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Inflammatory Response Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway
Pathways		mRNA Splicing - Major Pathway	Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Neurexins and neuroligins
Drugs
Diseases
GWAS		Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)	Asthma ( 31959851 32296059) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Serum metabolite levels ( 23093944) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		6 interacting genes: CENATAC PCBP1 SHARPIN SLU7 TAB2 TAB3	21 interacting genes: ACTR2 ACTR3 ITGA1 ITGA2B ITGA5 ITGAD ITGAL ITGAM ITGB2 KRTAP6-2 KRTAP7-1 PPIL3 SHANK1 SHANK2 TRAF1 TRIP13 TXN2 UBC USP54 YOD1 ZBTB32
Entrez ID		53938	81858
HPRD ID		15163	15463
Ensembl ID		ENSG00000240344	ENSG00000179526
Uniprot IDs		A0A024R3V4 A0A0S2Z5A8 Q9H2H8	Q6PJD5 Q9H0F6
PDB IDs		1XYH 2OJU 2OK3	4EMO 5X0W
Enriched GO Terms of Interacting Partners?
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