ZBTB4 and KLHL12

Data Source:
BioGRID (two hybrid)

		ZBTB4	KLHL12
Description		zinc finger and BTB domain containing 4	kelch like family member 12
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Body	Golgi Membrane Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Methyl-CpG Binding Methyl-CpNpG Binding Protein Kinase Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding	Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Negative Regulation Of Transcription, DNA-templated	Protein Monoubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			Degradation of DVL
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Corpus callosum posterior volume ( 31530798) Diverticular disease ( 30177863) Height ( 25282103 31562340) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Refractive error ( 32231278) Serum uric acid levels ( 30993211)
Interacting Genes		17 interacting genes: ANXA2 BANP CALCOCO2 CBFA2T3 CCDC57 CEP70 CEP76 CYSRT1 GOLGA2 HIPK2 HOMER3 KLHL12 PDE4DIP PIBF1 POU6F2 TP53BP2 TRIM23	62 interacting genes: ARAF ARRDC1 ATXN1 BAG6 BCL6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL1 DVL2 DVL3 FAM90A1 FBXL17 FGD2 FLNA GLYCTK INMT KHSRP KLHL2 KLHL24 KLHL3 LNPK LNX1 MAPRE1 MED25 MED28 MPP1 MRPL10 MTNR1A MYO15B NDC80 NTAQ1 PDGFRB PEA15 PEF1 PLEKHA4 PNKP PRR13 RGL3 RIN1 RIT1 RNF4 RPP25L SDCBP SEC31A SNX20 SYNE4 TAOK2 TBC1D10C TCEANC TTBK2 UBE2I VEGFB VTA1 ZBP1 ZBTB4
Entrez ID		57659	59349
HPRD ID		11693	13925
Ensembl ID		ENSG00000174282	ENSG00000117153
Uniprot IDs		B3KVD4 Q9P1Z0	Q53G59 Q9H7R2
PDB IDs			2VPJ 6TTK 6V7O
Enriched GO Terms of Interacting Partners?
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