KIF17 and MAP3K10

Data Source:
BioGRID (two hybrid)

		KIF17	MAP3K10
Description		kinesin family member 17	mitogen-activated protein kinase kinase kinase 10
Image		No pdb structure
GO Annotations	Cellular Component	Microtubule Organizing Center Cytosol Kinesin Complex Microtubule Cilium Axoneme Photoreceptor Connecting Cilium Dendrite Cytoplasm Ciliary Basal Body Neuron Projection Periciliary Membrane Compartment	Cytoplasm
	Molecular Function	Microtubule Motor Activity ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity	Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity ATP Binding Protein Homodimerization Activity BHLH Transcription Factor Binding
	Biological Process	Microtubule-based Movement Vesicle-mediated Transport Cell Projection Organization Intraciliary Transport Involved In Cilium Assembly Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex	Apoptotic Process Signal Transduction Smoothened Signaling Pathway JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Protein Autophosphorylation
Pathways		Intraflagellar transport Assembly and cell surface presentation of NMDA receptors
Drugs			Fostamatinib
Diseases
GWAS		Ceramide levels (C24:0) ( 32489964) Proportion of activated microglia (inferior temporal cortex) ( 30679421)	Birth weight ( 31043758) Resting heart rate ( 27798624)
Interacting Genes		7 interacting genes: APBA1 FHL5 GFI1B MAP3K10 MAP3K11 PHAF1 XPO1	31 interacting genes: ABL2 CDC42 CEACAM1 CLTC CNKSR1 COPS2 DLG4 DNM1 DNM1L GARS1 HGS HTT KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAP3K21 MAPK1 MAPK14 MAPK8IP1 MAPK8IP2 MAPK9 NEUROD1 PHB RAC1 RACGAP1 SH3RF1 SMURF1 TUBB YWHAE
Entrez ID		57576	4294
HPRD ID		10388	02533
Ensembl ID		ENSG00000117245	ENSG00000130758
Uniprot IDs		A0A0A0MRS8 Q9P2E2	Q02779
PDB IDs			2RF0
Enriched GO Terms of Interacting Partners?
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