ARRDC3 and CCDC50

Data Source:
BioGRID (two hybrid)

		ARRDC3	CCDC50
Description		arrestin domain containing 3	coiled-coil domain containing 50
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GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Early Endosome Plasma Membrane	Cytosol
	Molecular Function	Protein Binding Beta-3 Adrenergic Receptor Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Temperature Homeostasis Protein Transport Negative Regulation Of Heat Generation Skin Development Positive Regulation Of Ubiquitin-protein Transferase Activity Fat Pad Development Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Cold-induced Thermogenesis	Sensory Perception Of Sound
Pathways
Drugs
Diseases
GWAS		Breast cancer ( 29059683 25038754) Breast cancer (prognosis) ( 23319801) Breast cancer (survival) ( 25526632) Platelet distribution width ( 32888494) Subcutaneous adipose tissue ( 22589738)	Alzheimer's disease biomarkers ( 23562540) Lung cancer in never smokers ( 28604730)
Interacting Genes		40 interacting genes: ADRB2 BAG3 BCL6 CCDC50 CDA DCUN1D1 EFEMP2 EPN2 F2R FAM90A1 HPGDS ITCH MAGI2 MORF4L1 NEDD4L OPTN OTUB2 PDCD6IP PHF1 PRKAA2 RABGEF1 RACK1 RAD18 SMARCD1 STAM2 TNFAIP3 TOLLIP TRIM42 UBA52 UBAC1 UBASH3A UBE2D1 UBE2D2 UBE2E2 UBE2E3 UBQLN2 WWOX WWP1 WWP2 ZRANB1	7 interacting genes: ARRDC3 RIPK1 RNF8 RPS3A SH3GL1 TNFAIP3 UBC
Entrez ID		57561	152137
HPRD ID		09810	06463
Ensembl ID		ENSG00000113369	ENSG00000152492
Uniprot IDs		Q96B67	Q8IVM0
PDB IDs		4N7H 4R7V 4R7X	6LAN
Enriched GO Terms of Interacting Partners?
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