MIB1 and RMC1

Data Source:
BioGRID (affinity chromatography technology)

		MIB1	RMC1
Description		MIB E3 ubiquitin protein ligase 1	regulator of MON1-CCZ1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Postsynaptic Density Cytoplasmic Vesicle	Lysosomal Membrane Late Endosome Membrane Mon1-Ccz1 Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding	Protein Binding
	Biological Process	Blood Vessel Development In Utero Embryonic Development Somitogenesis Neural Tube Formation Heart Looping Ubiquitin-dependent Protein Catabolic Process Endocytosis Notch Signaling Pathway Protein Ubiquitination Negative Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis	Autophagy Regulation Of Autophagy
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Mean spheric corpuscular volume ( 32888494) Severe progression in rheumatoid arthritis ( 29065906)	FEV1 ( 30804560) Lung function (FVC) ( 30804560)
Interacting Genes		15 interacting genes: AZI2 BLM DAB2 DAPK1 EPB41L4A GABARAP JAG1 SNX5 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N UBE2U UBE2W	1 interacting genes: C11orf52
Entrez ID		57534	29919
HPRD ID		06660	12693
Ensembl ID		ENSG00000101752	ENSG00000141452
Uniprot IDs		Q86YT6	A0A087WZD4 B7Z201 B7Z2Y1 B7Z3Q1 K7ENL9 Q96DM3
PDB IDs		4TSE 4XI6 4XI7 4XIB
Enriched GO Terms of Interacting Partners?
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