KIDINS220 and NTRK3

Data Source:
HPRD (in vivo)

		KIDINS220	NTRK3
Description		kinase D interacting substrate 220	neurotrophic receptor tyrosine kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Late Endosome Cytosol Membrane Integral Component Of Membrane Protein-containing Complex	Plasma Membrane Integral Component Of Plasma Membrane Axon Receptor Complex
	Molecular Function	Protein Kinase Regulator Activity PDZ Domain Binding	P53 Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Neurotrophin Binding
	Biological Process	Activation Of MAPKK Activity In Utero Embryonic Development Positive Regulation Of Neuron Projection Development Nerve Growth Factor Signaling Pathway Dendrite Morphogenesis Cellular Response To Nerve Growth Factor Stimulus	Activation Of MAPK Activity Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Heart Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Kinase Activity Neurotrophin Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Positive Chemotaxis Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Activation Of GTPase Activity Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		ARMS-mediated activation ARMS-mediated activation	Receptor-type tyrosine-protein phosphatases NTF3 activates NTRK3 signaling NTF3 activates NTRK3 signaling Signaling by NTRK3 (TRKC) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through RAS Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K NTRK3 as a dependence receptor
Drugs			Entrectinib Fostamatinib Larotrectinib Pralsetinib
Diseases			Neuroblastoma
GWAS		Alcoholic chronic pancreatitis ( 28754779) HDL cholesterol levels ( 32109663) Neutrophil count ( 21507922) Skin aging measurement ( 31522824) Waist-hip ratio ( 28552196)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) Diabetic peripheral neuropathy in type 2 diabetes ( 31127053) Gaucher disease severity ( 22388998) General risk tolerance (MTAG) ( 30643258)
Interacting Genes		12 interacting genes: CDC73 CRKL FHL3 KRT34 MOB4 MYC NGFR NTRK1 NTRK2 NTRK3 PRKD1 SEPTIN5	28 interacting genes: APP BEX3 DOK5 DOK6 DYNLL1 ERBB2 FRS2 HEY1 HTR2A IRAK1 IRAK3 JUN KIDINS220 KPNA4 MAPK1 MAPK3 NELFB NGFR NSD1 NTF3 PLCG1 PTPN1 RASGRF1 SHC1 SHC2 SORT1 SQSTM1 WDR13
Entrez ID		57498	4916
HPRD ID		17235	01870
Ensembl ID		ENSG00000134313	ENSG00000140538
Uniprot IDs		Q9ULH0	B7Z7U4 O95193 Q16288 Q96CY4 X5D2R1 X5D7M5 X5DNW6
PDB IDs			1WWC 3V5Q 4YMJ 6KZC 6KZD
Enriched GO Terms of Interacting Partners?
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