HHATL and ADRA1A

Data Source:
BioGRID (two hybrid)

		HHATL	ADRA1A
Description		hedgehog acyltransferase like	adrenoceptor alpha 1A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Caveola Z Disc T-tubule Nuclear Membrane Intracellular Membrane-bounded Organelle Dopaminergic Synapse Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	Protein Binding Transferase Activity, Transferring Acyl Groups	G Protein-coupled Receptor Activity Alpha1-adrenergic Receptor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of N-terminal Protein Palmitoylation	Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Systemic Arterial Blood Pressure Apoptotic Process Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Adult Heart Development Aging Negative Regulation Of Cell Population Proliferation Response To Hormone Negative Regulation Of Autophagy Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Synaptic Transmission, GABAergic Negative Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Response To Drug Positive Regulation Of MAPK Cascade Positive Regulation Of Action Potential Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Micturition Calcium Ion Transport Into Cytosol Positive Regulation Of Cardiac Muscle Contraction Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Pilomotor Reflex Neuron-glial Cell Signaling Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Synaptic Vesicle Exocytosis
Pathways			Adrenoceptors G alpha (q) signalling events G alpha (12/13) signalling events
Drugs			Amphetamine Midodrine Ranolazine Ziprasidone Cabergoline Ropinirole Dapiprazole Amitriptyline Olanzapine Alfuzosin Clozapine Norepinephrine Mirtazapine Phenylephrine Loxapine Promazine Prochlorperazine Dipivefrin Droperidol Prazosin Prazosin Imipramine Chlorpromazine Chlorpromazine Buspirone Haloperidol Nortriptyline Amoxapine Amoxapine Lamotrigine Clonidine Doxazosin Labetalol Metaraminol Nicardipine Trazodone Verapamil Epinephrine Thioridazine Phentolamine Ergotamine Tizanidine Nicergoline Tamsulosin Paroxetine Methoxamine Trimipramine Risperidone Epinastine Propiomazine Tolazoline Fenoldopam Trifluoperazine Dobutamine Pseudoephedrine Benzphetamine Flupentixol Quinidine Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Ergoloid mesylate Promethazine Carvedilol Carvedilol Doxepin Nefazodone Desipramine Terazosin Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Ergometrine Paliperidone Bevantolol Ephedrine Mephentermine Methotrimeprazine 4-Methoxyamphetamine Dextroamphetamine Phendimetrazine Acepromazine Thioproperazine Zuclopenthixol Dronedarone Iloperidone Lofexidine R450 Epicept NP-1 Sertindole Mianserin Pizotifen Silodosin Asenapine Ocaperidone Droxidopa Xylometazoline Isometheptene Naphazoline Tetryzoline Perospirone Indoramin Dosulepin Etoperidone Lorpiprazole Cirazoline Synephrine Arotinolol Moxisylyte Aranidipine Niguldipine Pipamperone Racepinephrine Dihydroergocornine DL-Methylephedrine Indigotindisulfonic acid Propiverine Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS			Blood metabolite levels ( 24816252) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Response to amphetamines ( 22952603) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
Interacting Genes		20 interacting genes: ADRA1A AGTR1 AMIGO1 BDKRB1 C4orf3 CACNA1A CISD2 CPLX4 CXCL16 ERGIC3 FAM209A FKBP7 FNDC9 GPR152 GPX8 MILR1 MUC1 PVR SUSD3 TMX2	30 interacting genes: ABR ADGRA3 ADRA1B ADRA1D ANO8 ATP6AP2 BMP1 CD81 CXCR1 CXCR2 FAM241B FAM50B FLNC GDE1 GPR37 HHATL KIAA2013 KLHL22 MBOAT7 NOS1 NTNG2 PPP1R9B RGS2 SCN1B SGCB TBC1D20 TMEM234 TPCN2 UBR4 UGT8
Entrez ID		57467	148
HPRD ID		12166	00081
Ensembl ID		ENSG00000010282	ENSG00000120907
Uniprot IDs		A0A024R2R3 Q5QTR4 Q9HCP6	B0ZBD3 P35348
PDB IDs
Enriched GO Terms of Interacting Partners?
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