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ADRA1A and ADRA1D
Data Source:
HPRD
(two hybrid)
ADRA1A
ADRA1D
Description
adrenoceptor alpha 1A
adrenoceptor alpha 1D
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Caveola
Z Disc
T-tubule
Nuclear Membrane
Intracellular Membrane-bounded Organelle
Dopaminergic Synapse
Glutamatergic Synapse
GABA-ergic Synapse
Integral Component Of Postsynaptic Membrane
Integral Component Of Presynaptic Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
Molecular Function
G Protein-coupled Receptor Activity
Alpha1-adrenergic Receptor Activity
Protein Binding
Protein Heterodimerization Activity
G Protein-coupled Receptor Activity
Alpha1-adrenergic Receptor Activity
Protein Binding
Identical Protein Binding
Biological Process
Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure
Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure
Positive Regulation Of Heart Rate By Epinephrine-norepinephrine
Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine
Positive Regulation Of Systemic Arterial Blood Pressure
Apoptotic Process
Smooth Muscle Contraction
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cell-cell Signaling
Adult Heart Development
Aging
Negative Regulation Of Cell Population Proliferation
Response To Hormone
Negative Regulation Of Autophagy
Positive Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Synaptic Transmission, GABAergic
Negative Regulation Of Rho Protein Signal Transduction
Intracellular Signal Transduction
Response To Drug
Positive Regulation Of MAPK Cascade
Positive Regulation Of Action Potential
Positive Regulation Of Vasoconstriction
Positive Regulation Of Smooth Muscle Contraction
Micturition
Calcium Ion Transport Into Cytosol
Positive Regulation Of Cardiac Muscle Contraction
Cell Growth Involved In Cardiac Muscle Cell Development
Positive Regulation Of ERK1 And ERK2 Cascade
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Positive Regulation Of Protein Kinase C Signaling
Pilomotor Reflex
Neuron-glial Cell Signaling
Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity
Regulation Of Synaptic Vesicle Exocytosis
Positive Regulation Of Heart Rate By Epinephrine-norepinephrine
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Vasoconstriction
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Neuron-glial Cell Signaling
Pathways
Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Drugs
Amphetamine
Midodrine
Ranolazine
Ziprasidone
Cabergoline
Ropinirole
Dapiprazole
Amitriptyline
Olanzapine
Alfuzosin
Clozapine
Norepinephrine
Mirtazapine
Phenylephrine
Loxapine
Promazine
Prochlorperazine
Dipivefrin
Droperidol
Prazosin
Prazosin
Imipramine
Chlorpromazine
Chlorpromazine
Buspirone
Haloperidol
Nortriptyline
Amoxapine
Amoxapine
Lamotrigine
Clonidine
Doxazosin
Labetalol
Metaraminol
Nicardipine
Trazodone
Verapamil
Epinephrine
Thioridazine
Phentolamine
Ergotamine
Tizanidine
Nicergoline
Tamsulosin
Paroxetine
Methoxamine
Trimipramine
Risperidone
Epinastine
Propiomazine
Tolazoline
Fenoldopam
Trifluoperazine
Dobutamine
Pseudoephedrine
Benzphetamine
Flupentixol
Quinidine
Phenoxybenzamine
Maprotiline
Oxymetazoline
Apraclonidine
Ergoloid mesylate
Promethazine
Carvedilol
Carvedilol
Doxepin
Nefazodone
Desipramine
Terazosin
Escitalopram
Pergolide
Bromocriptine
Quetiapine
Aripiprazole
Ergometrine
Paliperidone
Bevantolol
Ephedrine
Mephentermine
Methotrimeprazine
4-Methoxyamphetamine
Dextroamphetamine
Phendimetrazine
Acepromazine
Thioproperazine
Zuclopenthixol
Dronedarone
Iloperidone
Lofexidine
R450
Epicept NP-1
Sertindole
Mianserin
Pizotifen
Silodosin
Asenapine
Ocaperidone
Droxidopa
Xylometazoline
Isometheptene
Naphazoline
Tetryzoline
Perospirone
Indoramin
Dosulepin
Etoperidone
Lorpiprazole
Cirazoline
Synephrine
Arotinolol
Moxisylyte
Aranidipine
Niguldipine
Pipamperone
Racepinephrine
Dihydroergocornine
DL-Methylephedrine
Indigotindisulfonic acid
Propiverine
Tiapride
Dihydroergocristine
Aripiprazole lauroxil
Amphetamine
Midodrine
Ranolazine
Cabergoline
Ropinirole
Dapiprazole
Amitriptyline
Alfuzosin
Norepinephrine
Mirtazapine
Phenylephrine
Prochlorperazine
Prazosin
Prazosin
Imipramine
Chlorpromazine
Buspirone
Nortriptyline
Amoxapine
Clonidine
Doxazosin
Labetalol
Nicardipine
Verapamil
Epinephrine
Phentolamine
Ergotamine
Tizanidine
Tamsulosin
Paroxetine
Methoxamine
Fenoldopam
Dobutamine
Quinidine
Phenoxybenzamine
Maprotiline
Oxymetazoline
Ergoloid mesylate
Promethazine
Carvedilol
Carvedilol
Doxepin
Desipramine
Terazosin
Escitalopram
Pergolide
Bromocriptine
Quetiapine
Mephentermine
Methotrimeprazine
Dextroamphetamine
Dronedarone
R450
Epicept NP-1
Sertindole
Mianserin
Pizotifen
Silodosin
Ocaperidone
Droxidopa
Xylometazoline
Perospirone
Dosulepin
Etoperidone
Lorpiprazole
Cirazoline
Synephrine
Arotinolol
Moxisylyte
Aranidipine
Pipamperone
Racepinephrine
Dihydroergocornine
DL-Methylephedrine
Indigotindisulfonic acid
Tiapride
Dihydroergocristine
Diseases
GWAS
Blood metabolite levels (
24816252
)
Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Response to amphetamines (
22952603
)
Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Paneth cell defects in Crohn's disease (
28352666
)
Preeclampsia (
23551011
)
Sense of smell (
26632684
)
Interacting Genes
30 interacting genes:
ABR
ADGRA3
ADRA1B
ADRA1D
ANO8
ATP6AP2
BMP1
CD81
CXCR1
CXCR2
FAM241B
FAM50B
FLNC
GDE1
GPR37
HHATL
KIAA2013
KLHL22
MBOAT7
NOS1
NTNG2
PPP1R9B
RGS2
SCN1B
SGCB
TBC1D20
TMEM234
TPCN2
UBR4
UGT8
8 interacting genes:
ADRA1A
FLNC
LNX1
NOS1
SNTA1
SNTB1
SNTB2
SNTG1
Entrez ID
148
146
HPRD ID
00081
00079
Ensembl ID
ENSG00000120907
ENSG00000171873
Uniprot IDs
B0ZBD3
P35348
B0ZBE0
P25100
PDB IDs
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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