ADAMTSL3 and KRTAP2-3

Data Source:
BioGRID (two hybrid)

		ADAMTSL3	KRTAP2-3
Description		ADAMTS like 3	keratin associated protein 2-3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Matrix Intracellular Membrane-bounded Organelle	Cytosol Keratin Filament
	Molecular Function	Metalloendopeptidase Activity Protein Binding	Protein Binding
	Biological Process	Proteolysis Extracellular Matrix Organization	Keratinization
Pathways		Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins	Keratinization Keratinization
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Appendicular lean mass ( 28724990) Asthma ( 32296059) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Childhood body mass index ( 33045005) Chronic obstructive pulmonary disease ( 30804561) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 21998595 28552196 20881960 25282103 25429064 19343178 23563607 31562340 18391950 18391951 18391952 20397748 20189936) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 28552196 25673412) Lean body mass ( 28724990) Optic disc size ( 31809533) Pulse pressure ( 30224653) Schizophrenia ( 28991256 25056061 29483656 30285260) Spine bone size ( 31053729) Waist circumference ( 26785701) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 26785701 25673412 28448500)
Interacting Genes		14 interacting genes: CYSRT1 GLRX3 KRT40 KRTAP1-1 KRTAP10-3 KRTAP10-6 KRTAP10-8 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP5-7 MDFI NOTCH2NLA	89 interacting genes: ADAMTSL3 BAHD1 BCL6B BEX2 C11orf87 CATSPER1 CHIC2 CREB5 CTSZ CXCL16 CYSRT1 DHX57 DMRT3 FAM161A GEMIN4 GGN HAPLN2 HHEX HOXA1 HOXB9 IGSF8 ITGB4 JOSD1 KLHL38 KRTAP1-1 KRTAP10-1 KRTAP12-4 KRTAP4-11 KRTAP4-12 KRTAP4-4 KRTAP5-11 KRTAP5-2 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LNX1 MCRS1 MOBP NBPF19 NKD1 NOTCH2NLA NPDC1 NUFIP2 OTX1 P2RY6 PHLDA1 PIGS PRKAB2 RHBDL1 SDC3 SHFL SPATA3 SPRED2 TFAP2D TNP2 TRIM42 TTPA VASN VWC2 YY1 ZBTB24 ZDHHC1 ZIM2 ZNF165 ZNF264 ZNF440 ZNF491 ZNF524 ZNF564 ZNF575 ZNF578 ZNF581 ZNF587 ZNF672 ZNF764 ZNF786 ZNF792
Entrez ID		57188	730755
HPRD ID		12426
Ensembl ID		ENSG00000156218	ENSG00000212724
Uniprot IDs		P82987	P0C7H8 Q9BYR9
PDB IDs
Enriched GO Terms of Interacting Partners?
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