SEPTIN3 and EIF6

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SEPTIN3	EIF6
Description		septin 3	eukaryotic translation initiation factor 6
Image
GO Annotations	Cellular Component	Septin Ring Microtubule Cytoskeleton Septin Complex Cell Division Site Neuron Projection Presynapse Presynaptic Cytoskeleton	Nucleus Lamin Filament Nucleoplasm Nucleolus Cytoplasm Cytosol Preribosome, Large Subunit Precursor Extracellular Exosome
	Molecular Function	Molecular_function GTPase Activity Protein Binding GTP Binding Identical Protein Binding Molecular Adaptor Activity	Translation Initiation Factor Activity Protein Binding Ribosome Binding Ribosomal Large Subunit Binding
	Biological Process	Cellular Protein Localization Cytoskeleton-dependent Cytokinesis	Ribosomal Subunit Export From Nucleus Maturation Of 5.8S RRNA Maturation Of LSU-rRNA Regulation Of Glycolytic Process Translational Initiation Response To Insulin Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Mature Ribosome Assembly Regulation Of Fatty Acid Biosynthetic Process Regulation Of Megakaryocyte Differentiation Positive Regulation Of Translation Assembly Of Large Subunit Precursor Of Preribosome Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Drugs			Copper
Diseases
GWAS			Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Fish- and plant-related diet ( 32066663) Height ( 18391951) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		18 interacting genes: CDC37 CHRM3 CKS1B DDIT4L EIF6 LASP1 MAPK6 MOB1A NTAQ1 PELI2 PRKG1 RNF4 RNF8 SDCBP SELENOF SEPTIN1 SLC39A14 WBP2	41 interacting genes: ABCF1 ACAP3 ACTG1 AKT1S1 ALDH2 APP CEP126 CLEC4G CRELD1 CSNK2B DHX58 EIF2AK2 ENOX1 FUNDC2 GIT1 HIP1 HPF1 ITGB4 LRIF1 MEOX2 MRPS31 MSRB3 OAS3 OFD1 OS9 PDHA1 PLK1 POLA2 PRKCB PSME1 PTEN RACK1 RPL6 SEPTIN3 TK1 UPF3B USP33 VAC14 WFS1 XRN2 ZBTB26
Entrez ID		55964	3692
HPRD ID		10515	04221
Ensembl ID		ENSG00000100167	ENSG00000242372
Uniprot IDs		Q9UH03	P56537
PDB IDs		3SOP 4Z51 4Z54 6UQQ	6LQM 6LSR 6LSS 6LU8
Enriched GO Terms of Interacting Partners?
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