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SMURF1 and PICALM
Data Source:
BioGRID
(enzymatic study)
SMURF1
PICALM
Description
SMAD specific E3 ubiquitin protein ligase 1
phosphatidylinositol binding clathrin assembly protein
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Axon
Neuronal Cell Body
Extracellular Exosome
Nucleus
Early Endosome
Golgi Apparatus
Cytosol
Plasma Membrane
Clathrin-coated Pit
Synaptic Vesicle
Cell Surface
Membrane
AP-2 Adaptor Complex
Clathrin Coat Of Coated Pit
Clathrin-coated Vesicle
Intrinsic Component Of Membrane
Vesicle
Presynaptic Membrane
Neuronal Cell Body
Intracellular Membrane-bounded Organelle
Postsynaptic Membrane
Clathrin-coated Endocytic Vesicle
Perinuclear Region Of Cytoplasm
Endosome To Plasma Membrane Transport Vesicle
Neurofibrillary Tangle
Extrinsic Component Of Presynaptic Endocytic Zone Membrane
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Phospholipid Binding
Activin Binding
Ubiquitin Protein Ligase Activity
I-SMAD Binding
R-SMAD Binding
SNARE Binding
Amyloid-beta Binding
Protein Binding
1-phosphatidylinositol Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Clathrin Binding
Small GTPase Binding
Clathrin Heavy Chain Binding
Cadherin Binding
Tau Protein Binding
Low-density Lipoprotein Particle Receptor Binding
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Export From Nucleus
Transforming Growth Factor Beta Receptor Signaling Pathway
Ectoderm Development
Protein Ubiquitination
Cell Differentiation
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Ubiquitin-dependent SMAD Protein Catabolic Process
Receptor Catabolic Process
Protein Localization To Cell Surface
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Engulfment Of Target By Autophagosome
Substrate Localization To Autophagosome
Protein Targeting To Vacuole Involved In Autophagy
Protein Localization To Plasma Membrane
Positive Regulation Of Dendrite Extension
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Endocytosis
Receptor-mediated Endocytosis
Vesicle Budding From Membrane
Axonogenesis
Learning Or Memory
Negative Regulation Of Gene Expression
Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane
Synaptic Vesicle Maturation
Vesicle-mediated Transport
Endosomal Transport
Hemopoiesis
Regulation Of Endocytosis
Receptor Internalization
Regulation Of Protein Localization
Vesicle Cargo Loading
Positive Regulation Of GTPase Activity
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Receptor-mediated Endocytosis
Clathrin Coat Assembly
Dendrite Morphogenesis
Iron Ion Homeostasis
Membrane Organization
Protein-containing Complex Assembly
Clathrin-dependent Endocytosis
Modulation Of Age-related Behavioral Decline
Regulation Of Vesicle Size
Membrane Bending
Amyloid-beta Clearance By Transcytosis
Positive Regulation Of Neuron Death
Regulation Of Amyloid-beta Formation
Positive Regulation Of Amyloid-beta Formation
Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Negative Regulation Of Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Negative Regulation Of Protein Localization To Plasma Membrane
Clathrin-coated Pit Assembly
Negative Regulation Of Protein Localization To Cell Surface
Pathways
Signaling by BMP
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Asymmetric localization of PCP proteins
Hedgehog 'on' state
Hedgehog 'on' state
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Antigen processing: Ubiquitination & Proteasome degradation
Golgi Associated Vesicle Biogenesis
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Drugs
Diseases
GWAS
Facial emotion recognition (sad faces) (
28608620
)
Inflammatory bowel disease (
28067908
23128233
)
Lack of premeditation (
30718321
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
)
Ulcerative colitis (
28067908
20228798
)
Alzheimer's disease (
22832961
19734902
21627779
31473137
)
Alzheimer's disease (late onset) (
21460841
30617256
24162737
)
Alzheimer's disease (onset between ages 58 and 79) (
30979435
)
Alzheimer's disease in APOE e4+ carriers (
25778476
)
Alzheimer's disease in APOE e4- carriers (
25778476
)
Alzheimer's disease or family history of Alzheimer's disease (
30617256
)
Alzheimer's disease or HDL levels (pleiotropy) (
30805717
)
Chronic obstructive pulmonary disease (
30804561
)
Family history of Alzheimer's disease (
30617256
)
Gut microbiota (bacterial taxa, rank normal transformation method) (
32572223
)
IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7) (
26741287
)
Mean platelet volume (
32888494
)
Platelet count (
32888494
27863252
)
Refractive error (
32231278
)
Tourette syndrome (
22889924
)
Interacting Genes
189 interacting genes:
ADRM1
ANAPC5
ANKRD13A
ANKRD13D
ANKRD50
ANKS4B
ANXA6
AP2B1
APBB2
APP
ARHGAP15
ARHGAP31
ARHGEF9
ARL14
ARL4D
ASCC2
ASH2L
ATXN3
AVEN
AXIN1
BMPR2
BTK
BTRC
C9orf78
CALCOCO1
CCDC69
CCM2
CDC40
CDK14
CDKL1
CSNK1D
CSNK2A2
CTNNB1
CTNND1
CTTN
CUEDC1
CUL5
CXXC1
DDX54
DNAJC7
DUSP13
DVL2
ECSIT
ELOF1
ELP3
ENTR1
EPHA1
EPN1
ETV6
FAF2
FBXL15
FBXO3
FBXO30
FCHO1
FES
FGF12
FGR
FKBP3
FSCN1
FZR1
GNG11
GRIPAP1
GRK3
HDGFL3
HIP1
HOMER2
ILRUN
IMPACT
ING2
INPP5B
IRAK2
ITGB1BP1
ITK
JUNB
KRT36
LATS1
LCK
LHX9
LIMS1
LMNA
LONRF3
MAP3K10
MAP3K2
MAP3K3
MAP3K9
MAP4K5
MARK2
MATK
MINDY3
MSN
NAA16
NDFIP2
NEDD8
NEK2
ODF2
OTUD6B
OXSR1
PADI4
PAK1
PAK1IP1
PDGFRA
PDLIM7
PICALM
PIP5K1C
PLEKHO1
POLR2A
PRKCA
PRKCG
PRKCI
PRR16
PSMD4
PSME3
PWP1
RABEP1
RAD23A
RASD2
RBCK1
RHOA
RHOB
RHPN2
RIOK3
RIPK2
RIT1
RNF11
RNF114
RNF141
RPS27A
RRP9
RTKN
RUNX3
SASH3
SCYL1
SENP8
SF3A1
SLAIN2
SMAD1
SMAD2
SMAD3
SMAD5
SMAD6
SMAD7
SPART
SQSTM1
SRSF4
SRSF5
STK31
STK35
STRAP
STUB1
TAB1
TAOK3
TBK1
TLN1
TNIK
TNIP2
TNK2
TNNT1
TOM1
TOM1L2
TPM4
TRAF4
TRIP10
TTC17
UBA52
UBAC1
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2G1
UBE2K
UBE2L3
UBE2M
UBE2V1
UBQLN1
UBQLN2
UBTF
UBXN1
UBXN6
UBXN7
USP45
USP5
USP9X
WDR61
WEE1
WFS1
XPO1
ZFAND5
19 interacting genes:
AP2A1
ATXN1
ATXN1L
CASP3
CASP8
CDC42
CLTC
CLTCL1
CRX
DDIT3
EHD2
FCHO1
ITSN1
PELI2
PLCG1
RBPMS
SMURF1
TENM1
ZC3H10
Entrez ID
57154
8301
HPRD ID
06902
04320
Ensembl ID
ENSG00000198742
ENSG00000073921
Uniprot IDs
Q9HCE7
A0A024R5L7
A0A024R5P1
Q13492
PDB IDs
2LAZ
2LB0
2LB1
2LTX
3PYC
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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