ATP13A1 and KMT2E

Data Source:
BioGRID (two hybrid)

		ATP13A1	KMT2E
Description		ATPase 13A1	lysine methyltransferase 2E (inactive)
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Chromatin Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Plasma Membrane Nuclear Body Nuclear Speck Protein-containing Complex Transcriptionally Active Chromatin
	Molecular Function	Molecular_function ATP Binding Manganese Transmembrane Transporter Activity, Phosphorylative Mechanism ATPase Activity Metal Ion Binding	Protein Binding Histone-lysine N-methyltransferase Activity Enzyme Binding Methylated Histone Binding Metal Ion Binding
	Biological Process	Cellular Calcium Ion Homeostasis Biological_process Ion Transmembrane Transport Manganese Ion Transmembrane Transport	Neutrophil Mediated Immunity DNA Methylation Cell Cycle Arrest Erythrocyte Differentiation Histone Lysine Methylation Neutrophil Activation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Histone H3-K4 Trimethylation
Pathways		Ion transport by P-type ATPases	PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Toenail selenium levels ( 25343990) White blood cell count ( 32888494)	Advanced age-related macular degeneration ( 26691988) Autism spectrum disorder ( 30804558) Autism spectrum disorder or schizophrenia ( 28540026) General risk tolerance (MTAG) ( 30643258) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494) Schizophrenia ( 29483656)
Interacting Genes		31 interacting genes: AGTR1 APPBP2 AQP6 ARHGEF5 BUD31 CBARP CXCR2 EBP ELOVL4 FAM209A FFAR2 GLP1R GPR42 KMT2E MANBAL MFSD14B MMD RNASEK SCN3B SLC10A6 SLC16A13 SLC30A2 SLC30A8 SLC35C2 SYPL2 TLCD4 TMBIM6 TMEM14B TMEM237 UNC93A VMA21	4 interacting genes: ASH2L ATP13A1 CDK1 LAMTOR5
Entrez ID		57130	55904
HPRD ID		12501	10528
Ensembl ID		ENSG00000105726	ENSG00000005483
Uniprot IDs		A0A024R7N2 Q9HD20	Q8IZD2
PDB IDs			2LV9 4L58 5HT6
Enriched GO Terms of Interacting Partners?
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