SLC17A7 and UNG

Data Source:
BioGRID (affinity chromatography technology)

		SLC17A7	UNG
Description		solute carrier family 17 member 7	uracil DNA glycosylase
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Integral Component Of Synaptic Vesicle Membrane Synaptic Vesicle Membrane Neuron Projection Intracellular Organelle Presynaptic Active Zone Excitatory Synapse Clathrin-sculpted Glutamate Transport Vesicle Membrane	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	L-glutamate Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Sodium:phosphate Symporter Activity Sodium:inorganic Phosphate Symporter Activity Transmembrane Transporter Activity	Damaged DNA Binding Uracil DNA N-glycosylase Activity Protein Binding Ribosomal Small Subunit Binding
	Biological Process	Neural Retina Development Ion Transport Phosphate Ion Transport Anion Transport Brain Development Glutamate Secretion L-glutamate Transmembrane Transport Synaptic Transmission, Glutamatergic Sodium Ion Transmembrane Transport Regulation Of Synapse Structure Or Activity Neurotransmitter Loading Into Synaptic Vesicle Regulation Of Synaptic Vesicle Endocytosis	DNA Repair Base-excision Repair Viral Process Somatic Hypermutation Of Immunoglobulin Genes Negative Regulation Of Apoptotic Process Depyrimidination Isotype Switching Base-excision Repair, AP Site Formation Via Deaminated Base Removal
Pathways		Glutamate Neurotransmitter Release Cycle Organic anion transporters
Drugs			4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACID 1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-4-METHYL-1H-INDOLE 3-[(1E,7E)-8-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-3,6-dioxa-2,7-diazaocta-1,7-dien-1-yl]benzoic acid
Diseases			Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
GWAS			Feeling miserable ( 29500382) Feeling worry ( 29500382) Neurociticism ( 29500382) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		1 interacting genes: SH3GL2	5 interacting genes: APP CAPN11 PCNA RPA2 SEZ6L2
Entrez ID		57030	7374
HPRD ID		05551	01881
Ensembl ID		ENSG00000104888	ENSG00000076248
Uniprot IDs		Q9P2U7	E5KTA5 E5KTA6 P13051
PDB IDs			1AKZ 1DPU 1EMH 1EMJ 1Q3F 1SSP 1UGH 1YUO 2HXM 2OXM 2OYT 2SSP 3FCF 3FCI 3FCK 3FCL 3TKB 4SKN 5AYR 5JK7
Enriched GO Terms of Interacting Partners?
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