PSMC1 and SUMO2

Data Source:
BioGRID (pull down)

		PSMC1	SUMO2
Description		proteasome 26S subunit, ATPase 1	small ubiquitin like modifier 2
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytosol Proteasome Regulatory Particle, Base Subcomplex Membrane Proteasome Accessory Complex	Nucleus Nucleoplasm PML Body
	Molecular Function	RNA Binding Protein Binding ATP Binding ATPase Activity TBP-class Protein Binding Proteasome-activating ATPase Activity	RNA Binding Protein Binding Protein Tag Ubiquitin Protein Ligase Binding Ubiquitin-like Protein Ligase Binding
	Biological Process	MAPK Cascade Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Protein Folding Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Deubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of MRNA Stability Post-translational Protein Modification T Cell Receptor Signaling Pathway Transmembrane Transport Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Interleukin-1-mediated Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Neuron Death Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Hematopoietic Stem Cell Differentiation	Protein Sumoylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL N-glycan trimming in the ER and Calnexin/Calreticulin cycle Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation	Vitamin D (calciferol) metabolism SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS		Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Seasonality and depression ( 30217971)	Deep white matter hyperintensities ( 32517579) Gamma glutamyl transferase levels ( 29403010) Type 2 diabetes ( 32499647)
Interacting Genes		38 interacting genes: APP ATXN7 CCDC85B CCND3 CNOT7 CRK FKBP8 HSPB1 JMJD1C JMJD6 KDM1A LINC01554 LNX1 MAGEA2 MAGEA2B MEOX2 MORF4L1 PAAF1 PAX4 PIAS3 PRKN PSMA7 PSMC2 PSMC4 PSMC5 PSMD2 PSMD5 PSMD7 PTGER4 STMN2 SUMO2 SUV39H1 TRAF6 UBASH3A UBC UBLCP1 VCP ZBTB8A	454 interacting genes: AARS1 ABCF1 ABRAXAS1 ACIN1 ACTB AHCYL1 AHNAK AHNAK2 AIMP1 ALAS1 ANAPC1 ANAPC2 ANLN ANXA1 APRT ARF3 ARF4 ARID2 ASNS ASS1 ATF7IP ATRX ATXN7 BABAM2 BAD BAZ1A BAZ1B BLM BOD1L1 BPTF BRCC3 BZW1 C18orf25 CAD CALM1 CARS1 CAST CCAR2 CCNE2 CCT2 CCT3 CCT4 CCT5 CCT6A CDK2 CENPC CHAF1A CHAF1B CHAMP1 CHD3 CHD4 CHD8 CKAP5 CLTC CMTM6 COPA COPB2 COPG1 CPSF2 CPSF7 CSE1L CSNK2B CTNNBL1 CTNND1 CTR9 CUL3 CUX1 DAB2 DARS1 DAXX DCD DDX1 DDX17 DDX21 DDX39A DDX39B DDX3X DDX5 DIDO1 DIP2B DNAJA1 DNM1L DNMT1 DYNC1H1 EDC4 EEF1A1 EEF1A2 EEF1G EEF2 EFTUD2 EGLN3 EHD4 EHMT1 EIF4A1 EIF4A2 EIF4G1 EIF4G2 EIF5A ELAC2 EME1 EMG1 EML3 ENO1 EP300 EP400 EPPK1 EPRS1 ERCC4 ERCC6 EXOSC10 EXOSC9 EZR FARSB FASN FBXO38 FLNA FLNB FOS GALK1 GAPVD1 GATAD2B GCN1 GEMIN5 GPATCH8 GTF2I GTF3C1 GTF3C2 GTF3C4 GYS1 HCFC1 HDAC1 HDAC2 HDAC4 HDAC9 HDLBP HIPK2 HK2 HMGXB4 HNRNPA0 HNRNPA1L2 HNRNPA2B1 HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPL HNRNPLL HNRNPM HNRNPR HNRNPU HOMEZ HP1BP3 HPS6 HSF2 HSP90AA1 HSP90AB1 HSPA1A HSPA5 HSPA8 HSPA9 HSPB1 HSPD1 HUWE1 IARS1 ILK IMPDH2 INTS3 IPO5 IQGAP1 JUN KALRN KARS1 KDM1A KDM5C KIF11 KIF18B KIF23 KIF2A KIF2C KIF4A KIF5B KPNA2 KRT8 LARS1 LAS1L LEF1 LMNA LMO7 MAF1 MAP4 MARS1 MAST2 MCM3 MCM4 MDC1 MDN1 MKI67 MMS19 MORC3 MPI MRE11 MSH2 MSH3 MSH6 MSX1 MTA1 MTA2 MTHFD1 MUS81 MYB MYG1 NAP1L1 NARS1 NAT10 NBN NCAPD2 NCAPD3 NCAPG NCAPH2 NCL NCOR1 NFATC2IP NFE2L2 NIBAN2 NIPBL NOL9 NONO NOP2 NPM1 NSUN2 NUMA1 NUP107 NUP160 NUP214 ORC3 P4HA1 P4HB PAF1 PALLD PARN PARP1 PBRM1 PDCD4 PDCD6IP PDS5A PELP1 PFKL PFKM PFKP PGK1 PHF3 PHF5A PHF8 PIAS1 PIAS2 PIAS3 PIAS4 PKM PKN2 PLEC PML POGZ POLA1 POLD1 POLR2A PPP1CC PPP2R1A PRC1 PRDX6 PRKDC PRPF6 PRPF8 PSMC1 PSMC3 PSMC4 PSMC5 PTBP1 RAD21 RAD50 RAD51 RAD54L2 RAN RANBP2 RANGAP1 RARS1 RBBP4 RBBP7 RCC1 RCOR1 RCOR2 RCOR3 RFC2 RFC4 RFC5 RIF1 RNF111 RNF168 RNF20 RNF213 RNF216 RNF4 RNF8 RPL10 RPL3 RPL4 RPS3 RPS4X RPS6KA3 RREB1 RRM1 RUVBL1 S100A10 SAE1 SAFB SAFB2 SAMHD1 SARS1 SART1 SCAF11 SENP1 SENP2 SENP3 SENP5 SENP6 SENP7 SERPINB6 SETDB1 SETX SF3A1 SF3B1 SF3B2 SIMC1 SIN3A SIRT1 SLC22A2 SLX4IP SMARCA4 SMARCAD1 SMC1A SMC2 SMC3 SMC4 SMCHD1 SND1 SNRNP200 SNW1 SNX27 SOBP SOX10 SOX6 SP1 SP100 SPATA5 SPATA5L1 SPR SPTAN1 SPTBN1 SRCAP SRP68 SRRM2 SRRT SSRP1 STAG2 STIP1 STRAP SUPT16H SUPT5H SYMPK SYNCRIP TAF1 TAGLN2 TCERG1 TCP1 TDG TDP2 TEAD3 TEX10 TK1 TLN1 TMPO TNIP1 TOP2A TOP2B TOPORS TP53BP1 TP53BP2 TPR TPX2 TRAF1 TRIM25 TRIM26 TRIM28 TRIM63 TRIML2 TRIP13 TRMT1L TSR1 TTI1 TTLL12 TUBA1B TUBA1C TUBA4A TUBB TUBB4A TUBB4B TUBB6 U2AF2 UBA1 UBA2 UBAP2L UBE2I UBR4 UIMC1 UMPS UPF1 USP11 USP25 USP28 USP48 USP5 USP7 USP9X USPL1 VARS1 VIM WAPL WASHC2C WDHD1 WRN XAB2 XPNPEP1 XPO1 XPO5 XRCC5 XRCC6 YWHAQ ZBED1 ZBTB2 ZBTB25 ZBTB33 ZBTB39 ZC3H11A ZCCHC12 ZCCHC7 ZHX1 ZMAT3 ZMYM2 ZMYM3 ZMYM4 ZMYM5 ZMYND8 ZNF451 ZNF496 ZNF638
Entrez ID		5700	6613
HPRD ID		04084	04332
Ensembl ID		ENSG00000100764	ENSG00000188612
Uniprot IDs		P62191 Q53XL8	A0A024R8S3 P61956
PDB IDs		5GJQ 5GJR 5L4G 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 5VHS 6MSB 6MSD 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN	1WM2 1WM3 1WZ0 1Z5Q 2AWT 2CKH 2D07 2IO0 2IO3 2IYD 2N1W 2N9E 2RPQ 3UIN 3UIO 3ZO5 4BKG 4NPN 5D2M 5ELU 5EQL 5GHB 5GHC 6JXW 6JXX
Enriched GO Terms of Interacting Partners?
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