PSMB10 and PSMA1

Data Source:
BioGRID (two hybrid, two hybrid)

		PSMB10	PSMA1
Description		proteasome 20S subunit beta 10	proteasome 20S subunit alpha 1
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Spermatoproteasome Complex	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Proteasome Core Complex Polysome Proteasome Core Complex, Alpha-subunit Complex Extracellular Exosome
	Molecular Function	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding	Lipopolysaccharide Binding RNA Binding Endopeptidase Activity Protein Binding
	Biological Process	MAPK Cascade Protein Polyubiquitination Cell Morphogenesis Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Humoral Immune Response Proteasomal Ubiquitin-independent Protein Catabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Protein Deubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway T Cell Proliferation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of MRNA Stability Post-translational Protein Modification T Cell Receptor Signaling Pathway Transmembrane Transport Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Interleukin-1-mediated Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Hematopoietic Stem Cell Differentiation	MAPK Cascade Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cellular Amino Acid Metabolic Process Proteasomal Ubiquitin-independent Protein Catabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Deubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of MRNA Stability Post-translational Protein Modification T Cell Receptor Signaling Pathway Transmembrane Transport Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Interleukin-1-mediated Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Carfilzomib	(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Diseases
GWAS		Crohn's disease ( 22412388) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Alzheimer's disease (cognitive decline) ( 23535033) Bipolar disorder ( 31043756) Diastolic blood pressure ( 27841878) HDL cholesterol levels ( 32203549) High chromosomal aberration frequency (total) ( 31586183) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549 32154731) Vitamin D levels ( 25208829)
Interacting Genes		11 interacting genes: ANXA7 CCNDBP1 CRX MEOX2 POMP PSMA1 PSMA2 PSMA3 PSMB8 PSMB9 PTN	169 interacting genes: ABCD3 ABI2 ABI3 ACTN1 ACTN2 AGR2 APIP APP BANF2 BLZF1 C11orf49 C22orf39 CABP5 CALCOCO2 CBS CCDC102B CCDC136 CCDC153 CCDC85B CCNH CDA CDKN2D CDR2 CEP70 CEP72 CFAP206 CHMP1A CINP COG4 COG6 COIL CRX DCTD DCTPP1 DDIT4L DEF6 DLEU1 DYDC1 DYNLT1 EHMT2 EIF4A3 EMSY ERBB2 FNDC11 GNPTAB GOLGA2 GOLGA6A GPHN GSDMD GUCD1 HEXIM2 HOMER3 HOMEZ HOOK2 HOXC11 HSD17B14 HSF2BP IFT20 IKZF1 IKZF3 INO80E IPO13 KAZN KCTD1 KCTD13 KCTD17 KCTD6 KCTD7 KCTD9 KHDRBS3 KRT13 KRT15 KRT19 KRT31 KRT34 KRT37 KRT38 KRT40 KRTAP1-1 KRTAP1-3 KRTAP4-1 KRTAP5-9 KRTAP6-3 LDB1 LDOC1 LMO2 LONRF1 LZTFL1 LZTS1 LZTS2 MAD1L1 MAPK1 MAPRE1 MAPRE3 MCM6 MID2 MIEF1 MKNK2 MKRN3 MLH1 MRFAP1L1 MSANTD4 MT-CO2 MTUS2 NAB2 NBPF19 NECAB2 NME7 NMI NOP53 NOTCH2NLA PCBD1 PCYT2 PICK1 PLK1 PM20D2 PNMA1 PNMA2 PNMA5 POLR1C POMP PPCDC PRDM14 PRIMPOL PRKN PRPH PSMA2 PSMA3 PSMA4 PSMA7 PSMB1 PSMB10 PSMB2 PSMB5 RAD54B RBCK1 REL RFC2 RGS19 ROPN1 SAT1 SFMBT1 SH3BP4 SH3GLB1 SLF2 SPDEF SSX2IP TCF12 TCF4 TDO2 TEKT4 TNFAIP1 TNR TRAF1 TRAF5 TRIM10 TRIM23 TRIM27 TRIM42 TRIM54 TSC22D4 UBXN11 VCP VIM VMAC WTAP YPEL5 ZFAND1 ZMYND19
Entrez ID		5699	5682
HPRD ID		01465	04170
Ensembl ID		ENSG00000205220	ENSG00000129084
Uniprot IDs		P40306	B4E0X6 P25786
PDB IDs		6AVO 6E5B 6HV3 6HV4 6HV5 6HV7 6HVA 6HVR 6HVS 6HVT 6HVU 6HVV 6HVW	4R3O 4R67 5A0Q 5GJQ 5GJR 5L4G 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6AVO 6E5B 6KWY 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6R70 6REY 6RGQ 6WJD 6WJN 6XMJ
Enriched GO Terms of Interacting Partners?
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