DUSP22 and MAP2K4

Data Source:
HPRD (in vitro, in vivo)

		DUSP22	MAP2K4
Description		dual specificity phosphatase 22	mitogen-activated protein kinase kinase 4
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Filamentous Actin Leading Edge Of Lamellipodium	Nucleus Cytosol Axon Dendrite Cytoplasm Perikaryon
	Molecular Function	Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity Protein Tyrosine Kinase Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration Peptidyl-tyrosine Dephosphorylation Regulation Of Cell Population Proliferation Positive Regulation Of JNK Cascade Negative Regulation Of Focal Adhesion Assembly Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity	Activation Of MAPK Activity Apoptotic Process Signal Transduction JNK Cascade Activation Of JUN Kinase Activity Response To Wounding Peptidyl-tyrosine Phosphorylation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of DNA Replication Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Mechanical Stimulus Cellular Response To Sorbitol Negative Regulation Of Motor Neuron Apoptotic Process
Pathways			Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Alopecia areata ( 25608926) Asthma (childhood onset) ( 31036433) Crohn's disease ( 26192919) Eosinophil counts ( 32888494) Inflammatory bowel disease ( 26192919) Male-pattern baldness ( 28196072) Non-albumin protein levels ( 29403010) Serum total protein level ( 29403010) Systemic lupus erythematosus ( 33536424) Takayasu arteritis ( 30498034)	Asthma ( 32296059) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Response to amphetamines ( 22952603)
Interacting Genes		5 interacting genes: HOXA1 MAP2K4 MAP2K7 MAPK14 MAPK8	43 interacting genes: AKT1 ALDOB APP ARRB1 ARRB2 CFLAR CYLC2 DUSP22 EFNA4 FBP2 FLNA FLNC GEMIN5 ITCH JUN LRRK2 MAP2K6 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K14 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K8 MAP4K2 MAPK1 MAPK10 MAPK12 MAPK14 MAPK8 MAPK8IP3 MAPK9 NBR1 RBBP8 SPAG9 STX17 TRIB1 UBC
Entrez ID		56940	6416
HPRD ID		13255	03213
Ensembl ID		ENSG00000112679	ENSG00000065559
Uniprot IDs		A0A384NLC8 Q9NRW4	P45985
PDB IDs		1WRM 4WOH 6L1S 6LMY 6LOT 6LOU 6LVQ 7C8S	3ALN 3ALO 3VUT
Enriched GO Terms of Interacting Partners?
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