PAK6 and CACNA1H

Data Source:
BioGRID (biochemical)

		PAK6	CACNA1H
Description		p21 (RAC1) activated kinase 6	calcium voltage-gated channel subunit alpha1 H
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Cell Junction	Voltage-gated Sodium Channel Complex Integral Component Of Plasma Membrane Voltage-gated Calcium Channel Complex Integral Component Of Membrane Neuron Projection
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Protein Binding Low Voltage-gated Calcium Channel Activity Metal Ion Binding Scaffold Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Neuron Projection Arborization Neuron Projection Extension	Muscle Contraction Muscle Organ Development Myoblast Fusion Regulation Of Heart Contraction Neuronal Action Potential Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Biosynthetic Process Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Cellular Response To Potassium Ion Regulation Of Membrane Potential Positive Regulation Of Calcium Ion-dependent Exocytosis Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential Inorganic Cation Transmembrane Transport Positive Regulation Of Acrosome Reaction
Pathways		Activation of RAC1	NCAM1 interactions
Drugs		Fostamatinib	Ergocalciferol Enflurane Isradipine Spironolactone Cinnarizine Verapamil Zonisamide Felodipine Nitrendipine Nifedipine Bepridil Mibefradil Flunarizine Cannabidiol Trimebutine Benidipine Manidipine Butamben Bioallethrin Bioallethrin Medical Cannabis Nabiximols
Diseases
GWAS		Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)	Blood protein levels ( 28240269) Eosinophil counts ( 32888494) Leukocyte telomere length ( 32109421)
Interacting Genes		20 interacting genes: APP AR CDC42 CDK1 DAPK1 ESR1 FBXO7 HSF2BP LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RAC1 RHOJ RHOV SEMA3B SNX2 TPD52L1	3 interacting genes: CCR4 GNG2 KCNMA1
Entrez ID		56924	8912
HPRD ID		06426	07442
Ensembl ID		ENSG00000137843	ENSG00000196557
Uniprot IDs		A0A024R9Q4 Q9NQU5	A0A1W2PQW2 B3KQH9 O95180
PDB IDs		2C30 2ODB 4KS7 4KS8 6QDR 6QDS
Enriched GO Terms of Interacting Partners?
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