PAK6 and SPG11

Data Source:
BioGRID (imaging technique)

		PAK6	SPG11
Description		p21 (RAC1) activated kinase 6	SPG11 vesicle trafficking associated, spatacsin
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Cell Junction	Nucleolus Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Axon Dendrite Cytoplasmic Vesicle Synapse
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Neuron Projection Arborization Neuron Projection Extension	Chemical Synaptic Transmission Axo-dendritic Transport Synaptic Vesicle Transport Axon Extension Phagosome-lysosome Fusion Involved In Apoptotic Cell Clearance Walking Behavior
Pathways		Activation of RAC1
Drugs		Fostamatinib
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)	Anti-Toxoplasma gondii IgG seropositivity ( 30610941) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		20 interacting genes: APP AR CDC42 CDK1 DAPK1 ESR1 FBXO7 HSF2BP LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RAC1 RHOJ RHOV SEMA3B SNX2 TPD52L1	1 interacting genes: SERTAD3
Entrez ID		56924	80208
HPRD ID		06426	07963
Ensembl ID		ENSG00000137843	ENSG00000104133
Uniprot IDs		A0A024R9Q4 Q9NQU5	Q96JI7
PDB IDs		2C30 2ODB 4KS7 4KS8 6QDR 6QDS
Enriched GO Terms of Interacting Partners?
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