PAK6 and DLL4

Data Source:
BioGRID (affinity chromatography technology)

		PAK6	DLL4
Description		p21 (RAC1) activated kinase 6	delta like canonical Notch ligand 4
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GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Cell Junction	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Notch Binding Calcium Ion Binding Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Neuron Projection Arborization Neuron Projection Extension	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Branching Involved In Blood Vessel Morphogenesis Blood Vessel Remodeling Aortic Valve Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Atrium Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Pericardium Morphogenesis Signal Transduction Notch Signaling Pathway Visual Perception Blood Circulation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Differentiation Dorsal Aorta Morphogenesis Cellular Response To Vascular Endothelial Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Notch Signaling Pathway Regulation Of Neurogenesis Ventral Spinal Cord Interneuron Fate Commitment Regulation Of Neural Retina Development Notch Signaling Involved In Heart Development Blood Vessel Lumenization Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		Activation of RAC1	Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus
Drugs		Fostamatinib
Diseases
GWAS		Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)	General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Malaria ( 31844061) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		20 interacting genes: APP AR CDC42 CDK1 DAPK1 ESR1 FBXO7 HSF2BP LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RAC1 RHOJ RHOV SEMA3B SNX2 TPD52L1	2 interacting genes: NOTCH1 NOTCH4
Entrez ID		56924	54567
HPRD ID		06426	05540
Ensembl ID		ENSG00000137843	ENSG00000128917
Uniprot IDs		A0A024R9Q4 Q9NQU5	Q9NR61
PDB IDs		2C30 2ODB 4KS7 4KS8 6QDR 6QDS	5MVX
Enriched GO Terms of Interacting Partners?
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