SMARCAD1 and TOPBP1

Data Source:
BioGRID (two hybrid, pull down)

		SMARCAD1	TOPBP1
Description		SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	DNA topoisomerase II binding protein 1
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GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Site Of Double-strand Break Nuclear Replication Fork	Condensed Nuclear Chromosome Spindle Pole Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Microtubule Organizing Center Plasma Membrane Actin Cytoskeleton Nuclear Body PML Body Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding DNA-dependent ATPase Activity Ubiquitin Binding	DNA Binding Protein Binding Protein C-terminus Binding Identical Protein Binding
	Biological Process	Regulation Of DNA Recombination DNA Double-strand Break Processing Chromatin Remodeling DNA Duplex Unwinding ATP-dependent Chromatin Remodeling Chromosome Separation Histone H3 Deacetylation Histone H4 Deacetylation	DNA Metabolic Process DNA Replication DNA Replication Initiation DNA Repair Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Response To Ionizing Radiation Mitotic DNA Replication Checkpoint Regulation Of Signal Transduction By P53 Class Mediator
Pathways			HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Capecitabine sensitivity ( 22864933) Colorectal cancer or advanced adenoma ( 30510241) Cortical surface area (MOSTest) ( 32665545) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549 28869591) Low susceptibility to hepatitis C infection ( 31206233) Menarche (age at onset) ( 25231870) QT interval ( 24952745 29874175) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604728 28604732 23666239) Type 2 diabetes ( 30297969)	Iron status biomarkers ( 19084217)
Interacting Genes		4 interacting genes: PCNA SUMO2 TOPBP1 TRIM28	32 interacting genes: ABL1 AKT1 ATM BLM BMPR2 BRIP1 CDC45 CHEK1 CLSTN1 E2F1 ESR1 FHL3 GINS1 HUS1 PML POLE PPHLN1 PPP1CC RAD1 RAD9A RAI1 RBBP8 RHNO1 SF3B2 SMARCAD1 TBC1D4 TCFL5 TEX11 TICRR TOP2B UBR5 ZBTB17
Entrez ID		56916	11073
HPRD ID		11586	09678
Ensembl ID		ENSG00000163104	ENSG00000163781
Uniprot IDs		Q9H4L7	A0AV47 A7E2X7 Q05BV8 Q92547
PDB IDs		6H3A 6QU1	1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO 6RML 6RMM
Enriched GO Terms of Interacting Partners?
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