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UBQLN4 and AREG
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
UBQLN4
AREG
Description
ubiquilin 4
amphiregulin
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Autophagosome
Endoplasmic Reticulum Membrane
Cytosol
Cytoplasmic Vesicle
Nuclear Proteasome Complex
Cytosolic Proteasome Complex
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Site Of DNA Damage
Golgi Membrane
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Membrane
Cell Surface
ER To Golgi Transport Vesicle Membrane
Integral Component Of Membrane
Clathrin-coated Vesicle Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Molecular Function
Protein Binding
Polyubiquitin Modification-dependent Protein Binding
K48-linked Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Cytokine Activity
Epidermal Growth Factor Receptor Binding
Protein Binding
Growth Factor Activity
Biological Process
DNA Repair
Ubiquitin-dependent Protein Catabolic Process
Autophagy
Cellular Response To DNA Damage Stimulus
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Autophagosome Maturation
Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
MAPK Cascade
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Keratinocyte Proliferation
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity
COPII Vesicle Coating
Positive Regulation Of Protein Kinase B Signaling
Membrane Organization
Pathways
PIP3 activates AKT signaling
Signaling by EGFR
GRB2 events in EGFR signaling
GAB1 signalosome
SHC1 events in EGFR signaling
EGFR downregulation
COPII-mediated vesicle transport
EGFR interacts with phospholipase C-gamma
Constitutive Signaling by Aberrant PI3K in Cancer
Inhibition of Signaling by Overexpressed EGFR
RAF/MAP kinase cascade
Cargo concentration in the ER
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Extra-nuclear estrogen signaling
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
Diseases
GWAS
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Body mass index (
29273807
)
Crohn's disease (
28067908
)
General risk tolerance (MTAG) (
30643258
)
Inflammatory bowel disease (
28067908
23128233
)
Blond vs. brown/black hair color (
30531825
)
Breast size (
22747683
27182965
)
Mammographic density (dense area) (
25342443
)
Spherical equivalent (joint analysis main effects and education interaction) (
27020472
)
Interacting Genes
161 interacting genes:
ADAM33
ADPGK
AGR2
ANKRD13D
AREG
ARL4C
ATP5IF1
ATP5MK
ATXN1
BAG6
BPIFA1
C11orf49
C1orf94
C1QTNF1
CACNA1G
CCDC107
CCDC134
CCDC136
CCDC14
CCDC33
CCL21
CD99
CDSN
CEND1
COL8A1
COPB1
CPSF6
CRIPT
CSTF2
CSTF2T
CTSB
CYB5R1
DAZAP2
DKK3
DMPK
DNAJB11
DTX2
EAPP
EDN1
EEF1A1
EFEMP2
ELF5
EPDR1
ERP27
ERP29
FA2H
FGFBP1
FKBP2
FKBP7
FZD7
GABRD
GDI1
GJA1
GJA5
GJC1
GKAP1
GPX7
HAVCR1
HGS
HK2
HSPA13
HSPA5
IGFBP6
IGHM
IGLC1
IMMT
IMPDH2
ITPRIPL1
KLHL26
KLHL42
LAT2
MDK
MDM2
MIEF2
MIF4GD
MLLT6
MOAP1
MTNR1B
MYDGF
NAE1
NME3
NOMO1
NOMO3
NOTCH2NLA
NPHP1
NPPA
NXF1
OAT
ORC5
PBXIP1
PCDH17
PCDH8
PDIA5
PDLIM7
PELI2
PICK1
PIN1
PIP4K2B
PLAAT3
PMEPA1
PNMA1
PPIB
PPIC
PRL
PRPF40A
PTN
PTPRN
PTPRN2
QSOX1
RAD23A
RAI2
RBM10
RIC8A
RNF11
RNPS1
ROBO2
RPN1
RSRC2
RUNX1T1
RXRA
SCAF1
SCG2
SCG5
SCMH1
SEMG1
SERPINE1
SERPINH1
SERPINI2
SMAD3
SMAD9
SMARCB1
SPAG8
SPINT1
SPP1
SRGN
SRSF2
STAM2
STMN1
SUPT20H
TFF1
TGFB1I1
TNFRSF14
TNRC6B
TRAF2
TRIB2
TRIM32
UBC
UBQLN1
UBQLN2
UBR7
UNC119
UROS
VIP
WAC
YWHAQ
ZBTB22
ZDHHC3
ZFPM2
ZG16
ZG16B
ZNF205
10 interacting genes:
APP
CCND3
CYSRT1
DNAAF10
EGFR
KRTAP10-3
KRTAP10-8
MMP9
UBQLN4
WT1
Entrez ID
56893
374
HPRD ID
05670
00093
Ensembl ID
ENSG00000160803
ENSG00000109321
Uniprot IDs
B4DZF6
Q59F94
Q9NRR5
P15514
PDB IDs
2RNL
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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