AREG and MMP9

Data Source:
HPRD (in vivo)

		AREG	MMP9
Description		amphiregulin	matrix metallopeptidase 9
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Cytokine Activity Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Identical Protein Binding
	Biological Process	MAPK Cascade Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Positive Regulation Of Keratinocyte Proliferation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity COPII Vesicle Coating Positive Regulation Of Protein Kinase B Signaling Membrane Organization	Skeletal System Development Ossification Positive Regulation Of Protein Phosphorylation Proteolysis Embryo Implantation Cytokine-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Macrophage Differentiation Positive Regulation Of Cell Migration Collagen Catabolic Process Cellular Response To Reactive Oxygen Species Endodermal Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation Of DNA Binding Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Keratinocyte Migration Cellular Response To Cadmium Ion Cellular Response To UV-A Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Neuroinflammatory Response Positive Regulation Of Receptor Binding Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cation Channel Activity Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Pathways		PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation COPII-mediated vesicle transport EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade Cargo concentration in the ER PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Signaling by SCF-KIT Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Extra-nuclear estrogen signaling
Drugs			Glutathione Marimastat Minocycline Captopril Glucosamine Zinc 2-Amino-N,3,3-Trimethylbutanamide 2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid AE-941 PG-530742 Endostatin 5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE (2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE (3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACID Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Penile cancer Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)
GWAS		Blond vs. brown/black hair color ( 30531825) Breast size ( 22747683 27182965) Mammographic density (dense area) ( 25342443) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472)	Abdominal aortic aneurysm ( 27899403) Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Coronary artery disease ( 33020668) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 23128233) Mild influenza (H1N1) infection ( 26379185) Systemic sclerosis ( 29293537)
Interacting Genes		10 interacting genes: APP CCND3 CYSRT1 DNAAF10 EGFR KRTAP10-3 KRTAP10-8 MMP9 UBQLN4 WT1	31 interacting genes: AREG BTC CD44 COL1A1 COL1A2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 CXCL1 CXCL5 CXCL6 CXCL8 EPHB2 FN1 HAPLN1 KISS1 LCN2 MMP10 MMP26 MMP7 PLG PRSS2 PZP RECK TFPI THBS1 THBS2 TIMP3
Entrez ID		374	4318
HPRD ID		00093	00387
Ensembl ID		ENSG00000109321	ENSG00000100985
Uniprot IDs		P15514	P14780
PDB IDs		2RNL	1GKC 1GKD 1ITV 1L6J 1LKG 2OVX 2OVZ 2OW0 2OW1 2OW2 4H1Q 4H2E 4H3X 4H82 4HMA 4JIJ 4JQG 4WZV 4XCT 5CUH 5I12 5TH6 5TH9 5UE3 5UE4 6ESM
Enriched GO Terms of Interacting Partners?
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