TRIM39 and GAMT

Data Source:
BioGRID (two hybrid)

		TRIM39	GAMT
Description		tripartite motif containing 39	guanidinoacetate N-methyltransferase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Guanidinoacetate N-methyltransferase Activity
	Biological Process	Apoptotic Process Mitotic G2 DNA Damage Checkpoint Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Protein Stabilization Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway	Creatine Metabolic Process Creatine Biosynthetic Process Muscle Contraction Spermatogenesis Animal Organ Morphogenesis Methylation Regulation Of Multicellular Organism Growth
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Creatine metabolism Transcriptional Regulation by MECP2
Drugs			Creatine Guanidine S-adenosyl-L-homocysteine Glycocyamine Phosphocreatine
Diseases			Creatine deficiency syndrome, including: Arginine:glycine amidinotransferase deficiency (AGAT deficiency); Guanidinoacetate methyltransferase deficiency (GAMT deficiency); X-linked creatine deficiency syndrome (XL-CDS) Guanidinoacetate methyltransferase (GAMT) deficiency
GWAS		Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Cutaneous lupus erythematosus ( 25827949) Neuroticism ( 29255261)
Interacting Genes		61 interacting genes: APP CACTIN CCNC DCUN1D1 DCX DIP2A EIF4A2 EPHB6 GAMT HINFP KDM1A LMNA LNX1 LXN MED18 MNAT1 MTURN OTUB2 OTUD6A PDLIM5 PLCD4 POLI PRPF3 PSMA6 PSMB1 PSMD9 RAD23A RECK RNF166 SMCO3 TP53 TRIM17 TRIM21 TRIM8 TTC32 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2N UBE2V1 UBE2W UBL5 UBTD1 UBTD2 UBXN1 UBXN6 UBXN7 USP2 USP39 USP5 WDFY3 ZKSCAN4 ZNF26	7 interacting genes: CSNK2B FOS POT1 RAB24 TERF1 TERF2IP TRIM39
Entrez ID		56658	2593
HPRD ID		09298	03142
Ensembl ID		ENSG00000204599	ENSG00000130005
Uniprot IDs		A0A024RCP5 A0A024RCR1 Q9HCM9	Q14353 V9HWB2
PDB IDs		2DID 2DIF 2ECJ	3ORH
Enriched GO Terms of Interacting Partners?
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