POLE4 and EVA1A

Data Source:
HPRD (in vitro)

		POLE4	EVA1A
Description		DNA polymerase epsilon 4, accessory subunit	eva-1 homolog A, regulator of programmed cell death
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Epsilon DNA Polymerase Complex	Lysosomal Membrane Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Protein Heterodimerization Activity	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process	Autophagy Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Cladribine
Diseases
GWAS			Chronotype ( 30696823) Gout ( 32238385) Seborrheic dermatitis ( 29203360)
Interacting Genes		7 interacting genes: HSPA13 NFYB POLE POLE2 POLE3 PRKAR1B UBE3A	8 interacting genes: GYPA MAP1LC3B MS4A13 MTNR1B PTN SAT1 SGTB TSPAN4
Entrez ID		56655	84141
HPRD ID		16238	07827
Ensembl ID		ENSG00000115350	ENSG00000115363
Uniprot IDs		Q9NR33	Q9H8M9
PDB IDs
Enriched GO Terms of Interacting Partners?
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