POLE4 and POLE3

Data Source:
HPRD (in vitro)

		POLE4	POLE3
Description		DNA polymerase epsilon 4, accessory subunit	DNA polymerase epsilon 3, accessory subunit
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Epsilon DNA Polymerase Complex	Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Epsilon DNA Polymerase Complex CHRAC
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Protein Heterodimerization Activity	DNA-directed DNA Polymerase Activity Protein Binding Chromatin DNA Binding Protein Heterodimerization Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Leading Strand Elongation Cellular Response To DNA Damage Stimulus Heterochromatin Assembly Telomere Maintenance Via Semi-conservative Replication Nucleosome Mobilization Histone H3 Acetylation DNA Biosynthetic Process
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs		Cladribine	Cladribine
Diseases
GWAS
Interacting Genes		7 interacting genes: HSPA13 NFYB POLE POLE2 POLE3 PRKAR1B UBE3A	7 interacting genes: APP BAZ1A CHRAC1 DR1 DRAP1 POLE4 SMARCA5
Entrez ID		56655	54107
HPRD ID		16238	06274
Ensembl ID		ENSG00000115350	ENSG00000148229
Uniprot IDs		Q9NR33	A0A024R829 Q9NRF9
PDB IDs
Enriched GO Terms of Interacting Partners?
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