POLE4 and HSPA13

Data Source:
BioGRID (two hybrid)

		POLE4	HSPA13
Description		DNA polymerase epsilon 4, accessory subunit	heat shock protein family A (Hsp70) member 13
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Epsilon DNA Polymerase Complex	Cytoplasm Mitochondrion Endoplasmic Reticulum Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Protein Heterodimerization Activity	Protein Binding ATP Binding ATPase Activity Heat Shock Protein Binding Protein Folding Chaperone Unfolded Protein Binding Misfolded Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process	Cellular Response To Unfolded Protein Protein Refolding Chaperone Cofactor-dependent Protein Refolding
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Regulation of HSF1-mediated heat shock response
Drugs		Cladribine	Copper
Diseases
GWAS
Interacting Genes		7 interacting genes: HSPA13 NFYB POLE POLE2 POLE3 PRKAR1B UBE3A	10 interacting genes: BAG6 CRYGA POLE4 RMI1 SGTA SGTB SSR1 UBQLN1 UBQLN2 UBQLN4
Entrez ID		56655	6782
HPRD ID		16238	03061
Ensembl ID		ENSG00000115350	ENSG00000155304
Uniprot IDs		Q9NR33	A0A140VK72 P48723
PDB IDs
Enriched GO Terms of Interacting Partners?
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