TMPRSS4 and RASGRP4

Data Source:
BioGRID (two hybrid)

		TMPRSS4	RASGRP4
Description		transmembrane serine protease 4	RAS guanyl releasing protein 4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Membrane Secretory Granule	Nucleoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Serine-type Endopeptidase Activity Scavenger Receptor Activity Protein Binding Serine-type Peptidase Activity	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Diacylglycerol Binding GTP-dependent Protein Binding
	Biological Process	Proteolysis Endocytosis Response To Wounding Regulation Of Gene Expression Protein Processing Negative Regulation Of Growth Rate Positive Regulation Of Viral Entry Into Host Cell	MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Phospholipase C Activity Small GTPase Mediated Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Population Proliferation Response To Extracellular Stimulus Myeloid Cell Differentiation Positive Regulation Of Ras Protein Signal Transduction
Pathways			FCERI mediated NF-kB activation RAF/MAP kinase cascade
Drugs
Diseases
GWAS			Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Diisocyanate-induced asthma ( 25918132) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		14 interacting genes: BNIP3L CLEC7A CLRN1 ERVFRD-1 FAM209A FNDC9 GPX8 KASH5 LMNA RASGRP4 SIGLEC12 SUSD3 SYNE4 TMEM79	6 interacting genes: BNIP2 DYNLL1 HRAS RAP1A SEC22A TMPRSS4
Entrez ID		56649	115727
HPRD ID		05952	09540
Ensembl ID		ENSG00000137648	ENSG00000171777
Uniprot IDs		B7Z458 B7Z8X1 B7Z900 Q9NRS4	Q8TDF6
PDB IDs			6AXG
Enriched GO Terms of Interacting Partners?
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