GBA and NEDD4

Data Source:
BioGRID (enzymatic study)

		GBA	NEDD4
Description		glucosylceramidase beta	NEDD4 E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Extrinsic Component Of Membrane Lysosomal Lumen Extracellular Exosome	Ubiquitin Ligase Complex Chromatin Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Cortex Apicolateral Plasma Membrane Protein-containing Complex Dendritic Spine Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Glucosylceramidase Activity Signaling Receptor Binding Scavenger Receptor Binding Protein Binding Glucosyltransferase Activity Steryl-beta-glucosidase Activity	Protein Binding Sodium Channel Inhibitor Activity Enzyme Binding Protein Domain Specific Binding Beta-2 Adrenergic Receptor Binding Ubiquitin Binding Phosphoserine Residue Binding Phosphothreonine Residue Binding Ubiquitin Protein Ligase Activity RNA Polymerase Binding Proline-rich Region Binding
	Biological Process	Glucosylceramide Catabolic Process Glycosphingolipid Metabolic Process Autophagy Mitochondrion Organization Lysosome Organization Cholesterol Metabolic Process Determination Of Adult Lifespan Cellular Response To Starvation Response To PH Microglia Differentiation Regulation Of Macroautophagy Antigen Processing And Presentation Lipid Storage Cerebellar Purkinje Cell Layer Formation Pyramidal Neuron Differentiation Termination Of Signal Transduction Lipid Glycosylation Neuron Projection Development Negative Regulation Of Protein-containing Complex Assembly Regulation Of TOR Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interleukin-6 Production T Cell Differentiation In Thymus Regulation Of Water Loss Via Skin Response To Testosterone Positive Regulation Of Protein Dephosphorylation Cell Death In Response To Oxidative Stress Positive Regulation Of Protein-containing Complex Disassembly Negative Regulation Of MAP Kinase Activity Negative Regulation Of Neuron Apoptotic Process Skin Morphogenesis Response To Estrogen Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Cell Maturation Brain Morphogenesis Homeostasis Of Number Of Cells Negative Regulation Of Inflammatory Response Neuromuscular Process Positive Regulation Of Protein Metabolic Process Neuron Apoptotic Process Microglial Cell Proliferation Motor Behavior Cellular Response To Tumor Necrosis Factor Hematopoietic Stem Cell Proliferation Response To Dexamethasone Lymphocyte Migration Response To Thyroid Hormone Negative Regulation Of Neuron Death Beta-glucoside Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Protein Lipidation Positive Regulation Of Neuronal Action Potential Positive Regulation Of Autophagy Of Mitochondrion In Response To Mitochondrial Depolarization Autophagosome Organization Regulation Of Lysosomal Protein Catabolic Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Lysosome Lysosomal Transport Neuromuscular Junction Development Negative Regulation Of Sodium Ion Transport Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Macroautophagy Protein Ubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Projection Development Receptor Internalization Receptor Catabolic Process Cellular Response To UV Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Glucocorticoid Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Development Involved In Symbiotic Interaction Positive Regulation Of Protein Catabolic Process Viral Budding Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Progesterone Receptor Signaling Pathway Response To Calcium Ion Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Glycosphingolipid metabolism Association of TriC/CCT with target proteins during biosynthesis	ISG15 antiviral mechanism Downregulation of ERBB4 signaling Regulation of PTEN localization Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs		scyllo-inositol N-acetyl-alpha-D-glucosamine Velaglucerase alfa (2R,3R,4R,5S)-2-(HYDROXYMETHYL)-1-NONYLPIPERIDINE-3,4,5-TRIOL
Diseases		Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Gaucher disease Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Dementia with Lewy bodies ( 29263008 31065058) Inflammatory bowel disease ( 28067908) Intracranial aneurysm ( 30823506) Parkinson's disease ( 22451204 25064009 27182965 24842889 28892059 21738487) Renal function-related traits (BUN) ( 22797727) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Brain connectivity ( 23471985) Chronic lymphocytic leukemia ( 28165464 24292274) Dupuytren's disease ( 28886342) Hip circumference adjusted for BMI ( 28552196) Intraocular pressure ( 29617998) Joint mobility (Beighton score) ( 27182965) Keloid ( 20711176) Refractive error ( 32231278) Stroke ( 29531354)
Interacting Genes		3 interacting genes: NEDD4 PSAP SNCA	238 interacting genes: ABCB1 ABL1 ABL2 ADRB2 AKT3 AMOT AMOTL1 AMPD2 ANKRD13D ANXA13 AP1G2 ARID1A ASPSCR1 AURKC BAIAP2 BMPR1A BRCA2 CAD CALCOCO1 CAMK1D CAMK4 CAMKK2 CASP1 CASP3 CASP6 CASP7 CBLB CCNH CDC25C CDK5 CDK5R1 CLIC2 CLK3 CPSF1 CPSF6 CUEDC1 DAZAP2 DCUN1D1 DDX3X DDX54 DHX30 DIAPH1 DVL1 DYRK4 EBAG9 EGFR EPHA5 EPRS1 EPS15 ERBB3 ERBB4 ERMN ERRFI1 FES FGF12 FGF21 FGFR1 FGFR2 FKBP3 FLT1 FLT4 FYN GABARAP GABARAPL1 GABARAPL2 GBA GFUS GRB10 GRIN2A GRK4 GRK7 H3-3A HGS HMCES HNRNPK HNRNPL HNRNPU HNRNPUL1 IFITM3 IGF1R IRS1 IRS2 JHY JUN KCNAB1 KCNAB2 KCNJ16 KIFC3 LAPTM5 LATS1 LINC01198 LITAF LUC7L2 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K2 MAP3K3 MAP3K5 MAP4K5 MAPKAPK3 MARK2 MARK4 MLANA MOB3A MRPL19 MTMR4 MYCN MYO15B N4BP2 N4BP3 NDFIP1 NDFIP2 NFE2 NHP2 NSRP1 NUDT21 NUMB PARP16 PAX7 PDGFRB PIP5K1A PIP5K1C PKN2 PLK1 PLK2 PMEPA1 POLR1C POLR2A POLR2B POLR2C POLR2E POLR2M POLR3A PRKG2 PRKX PRPF8 PRR16 PRRG1 PRRG2 PSMD4 PYM1 RAC1 RAD51AP1 RAF1 RANBP10 RAP2A RAPGEF2 RAPGEF6 RASGEF1A RASL11B RBCK1 RET RFT1 RNF11 RNF7 RPAP2 RPAP3 RPL18A RPS3A RPS6KA3 RPS6KA4 RPS6KB1 RUNX1 RUVBL1 SAAL1 SAMSN1 SAV1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SEPTIN9 SERTAD1 SFTPC SGK1 SGK2 SH3KBP1 SHISA6 SHTN1 SIVA1 SLC23A2 SLC6A3 SMAD1 SMAD3 SMAD5 SMARCC1 SMO SNCA SP140L SPANXN3 SPRY2 SRC SRMS SRSF7 STK24 STK25 STK26 STK31 STK4 SULF1 SYK SYT1 TAF1B TBC1D7 TBK1 TCEANC TCP11L1 TEAD2 THOC1 THRAP3 TNIK TOM1 TOM1L2 TP53BP2 TP73 TRIM44 TRIM52 TRPV6 TTYH2 UBAP2L UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L3 UBE2M UBOX5 URI1 VDAC2 VDAC3 WBP1 WBP2 WEE1 YES1 YOD1
Entrez ID		2629	4734
HPRD ID		06973	03786
Ensembl ID		ENSG00000177628	ENSG00000069869
Uniprot IDs		A0A068F658 B7Z6S9 P04062	P46934
PDB IDs		1OGS 1Y7V 2F61 2J25 2NSX 2NT0 2NT1 2V3D 2V3E 2V3F 2VT0 2WCG 2WKL 2XWD 2XWE 3GXD 3GXF 3GXI 3GXM 3KE0 3KEH 3RIK 3RIL 5LVX 6MOZ 6Q1N 6Q1P 6Q6K 6Q6L 6Q6N 6TJJ 6TJK 6TJQ 6TN1	2KPZ 2KQ0 2M3O 2XBB 2XBF 3B7Y 4BBN 4BE8 4N7F 4N7H 5AHT 5C7J 5C91
Enriched GO Terms of Interacting Partners?
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