PROS1 and ARL6

Data Source:
BioGRID (affinity chromatography technology)

		PROS1	ARL6
Description		protein S	ADP ribosylation factor like GTPase 6
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Golgi Lumen Plasma Membrane Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Cytoplasm Axonemal Microtubule Plasma Membrane Cilium Axoneme Membrane Membrane Coat Extracellular Exosome
	Molecular Function	Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding	GTPase Activity Protein Binding GTP Binding Phospholipid Binding Metal Ion Binding
	Biological Process	Platelet Degranulation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Blood Coagulation Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Fibrinolysis Leukocyte Migration	Protein Targeting To Membrane Intracellular Protein Transport Determination Of Left/right Symmetry Visual Perception Wnt Signaling Pathway Vesicle-mediated Transport Melanosome Transport Protein Polymerization Cilium Assembly Protein Localization To Cilium
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Complement cascade	BBSome-mediated cargo-targeting to cilium
Drugs		Drotrecogin alfa Menadione Sodium tetradecyl sulfate Kappadione
Diseases		Inherited thrombophilia	Bardet-Biedl syndrome (BBS) Retinitis pigmentosa (RP)
GWAS		Systemic lupus erythematosus ( 28714469)	Male infertility ( 19478329)
Interacting Genes		10 interacting genes: C4BPA C4BPB F10 F2 F5 F8 PROC RPSA TBK1 TYRO3	6 interacting genes: ARL6IP1 ARL6IP4 ARL6IP5 ARL6IP6 ATL2 SEC61B
Entrez ID		5627	84100
HPRD ID		01473	10588
Ensembl ID		ENSG00000184500	ENSG00000113966
Uniprot IDs		A0A0S2Z4K3 A0A0S2Z4L3 P07225	Q9H0F7
PDB IDs		1Z6C	2H57
Enriched GO Terms of Interacting Partners?
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