PRODH and SKIV2L

Data Source:
BioGRID (affinity chromatography technology)

		PRODH	SKIV2L
Description		proline dehydrogenase 1	Ski2 like RNA helicase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Intracellular Membrane-bounded Organelle	Nucleus Cytosol Ski Complex
	Molecular Function	Proline Dehydrogenase Activity FAD Binding	RNA Binding RNA Helicase Activity Protein Binding ATP Binding
	Biological Process	Proline Metabolic Process Proline Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Proline Catabolic Process To Glutamate Positive Regulation Of Cell Death 4-hydroxyproline Catabolic Process	RNA Catabolic Process Exonucleolytic Catabolism Of Deadenylated MRNA Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay
Pathways		Proline catabolism	Association of TriC/CCT with target proteins during biosynthesis mRNA decay by 3' to 5' exoribonuclease
Drugs		Proline
Diseases		Hyperprolinemia (HP)
GWAS		Amino acid levels ( 26068415) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Metabolic traits ( 21886157) Metabolite levels ( 31628463) Neutrophil count ( 32888494) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma free proline levels ( 30659259) Platelet count ( 32888494) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 25569235) White blood cell count ( 32888494)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 23577725 20861866) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood metabolite levels ( 24816252) Blood protein levels ( 29875488 28240269) Coronary artery disease ( 29212778) Disease progression in age-related macular degeneration ( 29346644) Inflammatory bowel disease ( 28067908) Platelet count ( 32888494) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908) vWF levels ( 30586737)
Interacting Genes			14 interacting genes: CACNB3 CDK11A CDKL5 EXOSC10 EXOSC4 GALNT13 PMPCA PRKAA2 RHOU SNRPB TNRC17 TSSK2 WDR1 XRN1
Entrez ID		5625	6499
HPRD ID		08433	02724
Ensembl ID		ENSG00000100033	ENSG00000204351
Uniprot IDs		O43272	A0A1U9X8J1 Q15477
PDB IDs
Enriched GO Terms of Interacting Partners?
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