PRODH and RANBP1

Data Source:
BioGRID (affinity chromatography technology)

		PRODH	RANBP1
Description		proline dehydrogenase 1	RAN binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Intracellular Membrane-bounded Organelle	Nucleus Nuclear Envelope Nuclear Pore Cytoplasm Centrosome Cytosol
	Molecular Function	Proline Dehydrogenase Activity FAD Binding	GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Cadherin Binding
	Biological Process	Proline Metabolic Process Proline Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Proline Catabolic Process To Glutamate Positive Regulation Of Cell Death 4-hydroxyproline Catabolic Process	Signal Transduction Viral Process Positive Regulation Of GTPase Activity Positive Regulation Of Mitotic Centrosome Separation Intracellular Transport
Pathways		Proline catabolism	Rev-mediated nuclear export of HIV RNA
Drugs		Proline	Copper Phenethyl Isothiocyanate
Diseases		Hyperprolinemia (HP)
GWAS		Amino acid levels ( 26068415) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Metabolic traits ( 21886157) Metabolite levels ( 31628463) Neutrophil count ( 32888494) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma free proline levels ( 30659259) Platelet count ( 32888494) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 25569235) White blood cell count ( 32888494)
Interacting Genes			7 interacting genes: CD93 KPNB1 MDM2 NUPR1 RAN RANGRF RCC1
Entrez ID		5625	5902
HPRD ID		08433	03110
Ensembl ID		ENSG00000100033	ENSG00000099901
Uniprot IDs		O43272	A0A140VK94 B3KUP2 B4DE76 D3DX26 F6WQW2 P43487
PDB IDs			1K5D 1K5G
Enriched GO Terms of Interacting Partners?
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