MAP2K5 and EPHA2

Data Source:
BioGRID (fluorescent resonance energy transfer)

		MAP2K5	EPHA2
Description		mitogen-activated protein kinase kinase 5	EPH receptor A2
Image
GO Annotations	Cellular Component	Nucleus Spindle Cytosol	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Lamellipodium Leading Edge Membrane Lamellipodium Membrane Ruffle Membrane Neuron Projection Receptor Complex Tight Junction
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Virus Receptor Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Cadherin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Activation Of MAPK Activity Signal Transduction Heart Development Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Growth Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-8 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Cytokine Stimulus ERK5 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Skeletal System Development Vasculogenesis Osteoblast Differentiation Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Inflammatory Response Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Lamellipodium Assembly Notochord Formation Cell Migration Negative Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Neural Tube Development Keratinocyte Differentiation Osteoclast Differentiation Negative Regulation Of Chemokine Production Mammary Gland Epithelial Cell Proliferation Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Kinase Activity Post-anal Tail Morphogenesis Protein Kinase B Signaling Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis CAMP Metabolic Process Viral Entry Into Host Cell Bone Remodeling Ephrin Receptor Signaling Pathway Axial Mesoderm Formation Cell Motility Defense Response To Gram-positive Bacterium Negative Regulation Of Protein Kinase B Signaling Notochord Cell Development Cell Chemotaxis Branching Involved In Mammary Gland Duct Morphogenesis Lens Fiber Cell Morphogenesis Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Protein Localization To Plasma Membrane Activation Of GTPase Activity Negative Regulation Of Lymphangiogenesis Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Bicellular Tight Junction Assembly Pericyte Cell Differentiation
Pathways		Signalling to ERK5	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs		Fostamatinib	Dasatinib Phosphoaminophosphonic Acid-Adenylate Ester Regorafenib Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Asthma ( 31959851) Bipolar disorder or body mass index ( 31754094) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28552196 22344219 26961502 24861553 28892062 25673413 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Dental caries (decayed and filled deciduous teeth) ( 31533690) Menarche (age at onset) ( 25231870) Motion sickness ( 25628336) Obesity ( 23563607) Proportion of activated microglia (midfrontal cortex) ( 30679421) Restless legs syndrome ( 17637780 29029846 21779176) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32154731) Type 2 diabetes ( 30297969 32499647) Verbal declarative memory ( 25648963) Waist circumference ( 25673412) Weight ( 28552196)	Blood protein levels ( 30072576) Gamma glutamyl transferase levels ( 29403010) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757)
Interacting Genes		55 interacting genes: AKT1 ARAF ARNT ASRGL1 BAD BECN1 C3orf36 CCND2 CD44 CDC42BPB CDK4 CDK6 CDKN2A CDKN2B CDKN2C DUSP21 EPHA2 ERBB2 ESRRA FGFR4 FZR1 GLIS2 GRM1 GUCD1 HGF HIF1A LATS2 LNX2 MAP2K3 MAP2K6 MAP3K2 MAP3K3 MAPK7 MDM4 MET MYC NF2 PARD6A PDGFRA PFDN5 PRKCI PRKCZ RAF1 RPL28 SQSTM1 STAMBP STK11 TEAD2 TERT TP53 TSC1 XRCC6 YWHAZ ZNF426 ZNF620	84 interacting genes: ABCB5 ACP1 AKT1 APP ARAF ARNT AURKA BECN1 CBL CBLC CCND2 CD44 CDC42 CDH5 CDK17 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CLDN4 DUSP14 DUSP18 DUSP19 DUSP26 DUSP29 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EGFR ERBB2 FGFR4 FZR1 GATAD1 GLIS2 GRB2 GRK2 GRM1 HGF HIF1A ILKAP KDELR2 KPNA3 LATS2 LSM7 MAP2K5 MAP2K6 MAPK14 MDM4 MET MSH2 MYC NF1 NF2 NFIC NUDT9 PDGFRA PIK3R1 PIK3R2 PPM1L PSME2 PTEN PTK2 PTPN11 PTPN7 PTPRR RAF1 RASA1 RASSF1 RBL1 RELA SHC1 SLA STK11 STYX TEAD2 TIAM1 TNFAIP1 TP53 TPTE TPTE2 UBE4A
Entrez ID		5607	1969
HPRD ID		03951	01494
Ensembl ID		ENSG00000137764	ENSG00000142627
Uniprot IDs		A0A024R5X5 A0A024R5Y2 Q13163	A0A024QZA8 P29317
PDB IDs		2NPT 2O2V 4IC7	1MQB 2E8N 2K9Y 2KSO 2X10 2X11 3C8X 3CZU 3FL7 3HEI 3HPN 3KKA 3MBW 3MX0 3SKJ 4P2K 4PDO 4TRL 5EK7 5I9U 5I9V 5I9W 5I9X 5I9Y 5I9Z 5IA0 5IA1 5IA2 5IA3 5IA4 5IA5 5NJZ 5NK0 5NK1 5NK2 5NK3 5NK4 5NK5 5NK6 5NK7 5NK8 5NK9 5NKA 5NKB 5NKC 5NKD 5NKE 5NKF 5NKG 5NKH 5NKI 5NZ9 6B9L 6F7M 6F7N 6FNF 6FNG 6FNH 6HES 6HET 6HEU 6HEV 6HEW 6HEX 6HEY 6NJZ 6NK0 6NK1 6NK2 6NKP 6Q7B 6Q7C 6Q7D 6Q7E 6Q7F 6Q7G 6RW2 7CZE 7CZF
Enriched GO Terms of Interacting Partners?
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