PSENEN and CRB3

Data Source:
BioGRID (two hybrid)

		PSENEN	CRB3
Description		presenilin enhancer, gamma-secretase subunit	crumbs cell polarity complex component 3
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Integral Component Of Membrane Golgi Cisterna Membrane Gamma-secretase Complex	Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane Apical Plasma Membrane Cell Junction Protein-containing Complex Extracellular Exosome
	Molecular Function	Protein Binding Enzyme Binding Endopeptidase Activator Activity	Protein Binding SH3 Domain Binding Protein Domain Specific Binding
	Biological Process	Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Positive Regulation Of Endopeptidase Activity Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Notch Receptor Processing, Ligand-dependent Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway	Bicellular Tight Junction Assembly Protein Localization To Plasma Membrane Positive Regulation Of Cell Junction Assembly
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation	Tight junction interactions
Drugs		E-2012
Diseases		Acne inversa; Hidradenitis supprativa
GWAS		Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: APH1A CRB3 CREB3 NCSTN PSEN1 PSEN2 SLC10A2 SLC10A6 THBD TMED10	28 interacting genes: ANKRD46 BCL2L13 BET1 FUNDC2 HMOX1 HMOX2 NDUFA3 PALS1 PARD6A PATJ PLLP PLP2 PSENEN PSMA3 RABAC1 SERF1A SERF1B SERP1 SLC39A9 STX5 TECR TMEM222 TREX1 UBIAD1 VAMP1 VTI1B WDR83 YIPF6
Entrez ID		55851	92359
HPRD ID		06362	16749
Ensembl ID		ENSG00000205155	ENSG00000130545
Uniprot IDs		Q9NZ42	Q9BUF7
PDB IDs		5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC	5I7Z
Enriched GO Terms of Interacting Partners?
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