EAF2 and NECAB2

Data Source:
BioGRID (two hybrid)

		EAF2	NECAB2
Description		ELL associated factor 2	N-terminal EF-hand calcium binding protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Transcription Elongation Factor Complex Nuclear Speck Super Elongation Complex	Cytoplasm Plasma Membrane Axon Dendrite
	Molecular Function	Transcription Elongation Regulator Activity Protein Binding	Calcium Ion Binding Protein Binding A2A Adenosine Receptor Binding Type 5 Metabotropic Glutamate Receptor Binding
	Biological Process	Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Apoptotic Process Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Adenosine Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Protein Localization To Membrane
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Body mass index (change over time) ( 25378290) Corneal astigmatism ( 29422769) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Rheumatoid arthritis ( 30891314)
Interacting Genes		20 interacting genes: BEND7 BIRC2 ELL GOLGA2 HIF1A IHO1 LNX2 NECAB2 PNMA1 PSME3 RBPMS SSX2IP STAC3 TCEA1 TCEA2 TFIP11 TFPT TLE5 TP53 TRIM23	89 interacting genes: ADORA2A AIMP2 BEX2 BEX3 BYSL C19orf25 C1orf109 C1orf216 CAGE1 CAPN3 CARD9 CCDC121 CCDC146 CCDC153 CCDC33 CCNK CDC37 CENPO CPEB2 DAXX DFFA DGCR6 DGCR6L DTNBP1 DYNC1I2 EAF2 EHHADH EIF4E2 EMILIN1 FAM161A FAM161B FANCG FXR2 GCC1 GOLGA2 GTPBP10 HAUS1 INPP1 INTS10 ISCU KANK2 KANSL1 KDM1A KIFC3 KLC3 KLC4 KPNA2 LENG1 LNX1 MED14 MRPS27 MSGN1 MTMR9 MYO15B MYPOP NECAB1 NEK6 NIP7 NOC4L NTAQ1 ODAD3 ODAD4 OIP5 PATJ PCM1 PICK1 POLR2C PRKAA2 PRPF18 PSMA1 PUS10 RCOR3 RIC8A RUNX1T1 SDCBP SH2D4A SMARCD1 SNAPIN SOGA1 SSC5D TCEA2 TEX11 TRIM59 TRIML2 TTR USHBP1 USP7 VTA1 ZNF655
Entrez ID		55840	54550
HPRD ID		09634	13263
Ensembl ID		ENSG00000145088	ENSG00000103154
Uniprot IDs		B4DWJ3 Q96CJ1	Q7Z6G3
PDB IDs
Enriched GO Terms of Interacting Partners?
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