VPS11 and VPS39

Data Source:
BioGRID (two hybrid)

		VPS11	VPS39
Description		VPS11 core subunit of CORVET and HOPS complexes	VPS39 subunit of HOPS complex
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Clathrin-coated Vesicle Endocytic Vesicle HOPS Complex Late Endosome Membrane	Cytoplasm Lysosomal Membrane Membrane AP-3 Adaptor Complex HOPS Complex Late Endosome Membrane
	Molecular Function	Nucleotide Binding Protein Binding Protein Domain Specific Binding Syntaxin Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Vacuole Organization Endosome To Lysosome Transport Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Regulation Of Organelle Assembly Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Early Endosome To Late Endosome Transport	Intracellular Protein Transport Autophagy Endosome To Lysosome Transport Endosomal Vesicle Fusion Late Endosome To Lysosome Transport Retrograde Transport, Endosome To Plasma Membrane
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 29273807) Coronary artery disease ( 29212778 33020668) HDL cholesterol levels ( 32203549) Plateletcrit ( 32888494)
Interacting Genes		33 interacting genes: BCAR1 BMI1 ECPAS EZR GGA3 KDM1A KRTAP10-3 KRTAP10-8 LRSAM1 LSM1 MARK3 MON1B MSN RAB7A RDX RILP RNF181 STX1A STX6 STX7 STX8 TFAP2B TRIM32 TSG101 UBE2D2 UBE2L3 UBE2U UVRAG VPS16 VPS18 VPS33A VPS39 VPS45	7 interacting genes: HOOK1 RAB7A RILP SNW1 STAT3 TFIP11 VPS11
Entrez ID		55823	23339
HPRD ID		12258	10300
Ensembl ID		ENSG00000160695	ENSG00000166887
Uniprot IDs		A0A087WXL6 B7Z879 Q9H270	A0A024R9L9 Q96JC1
PDB IDs			6ZE9
Enriched GO Terms of Interacting Partners?
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