NGLY1 and OPA3

		NGLY1	OPA3
Description		N-glycanase 1	outer mitochondrial membrane lipid metabolism regulator OPA3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Mitochondrion
	Molecular Function	Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Metal Ion Binding
	Biological Process	Protein Folding Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Glycoprotein Catabolic Process Protein Deglycosylation	Visual Perception Regulation Of Lipid Metabolic Process Response To Stimulus
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Drugs
Diseases			3-Methylglutaconic aciduria (MGCA) Autosomal dominant optic atrophy (DOA); Kjer's optic neuropathy
GWAS			Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Depression and alcohol dependence ( 22064162)
Interacting Genes		18 interacting genes: APP BICRAL FAF1 GUCD1 NPAS2 NSFL1C PAX5 PAX6 RAD23A RAD23B SRPK2 TCF12 TRAFD1 TRIM54 UBQLN1 UBXN2B VCP VMAC	5 interacting genes: APP KDM1A PRMT6 SUV39H1 UBC
Entrez ID		55768	80207
HPRD ID		10118	05956
Ensembl ID		ENSG00000151092	ENSG00000125741
Uniprot IDs		Q96IV0	B4DK77 Q9H6K4
PDB IDs		2CCQ 2CM0
Enriched GO Terms of Interacting Partners?
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