PRKACG and CDK17

Data Source:
BioGRID (two hybrid)

		PRKACG	CDK17
Description		protein kinase cAMP-activated catalytic subunit gamma	cyclin dependent kinase 17
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Ciliary Base	Nucleus Cytoplasm
	Molecular Function	AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Protein Kinase A Regulatory Subunit Binding	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Renal Water Homeostasis Protein Phosphorylation Spermatogenesis Blood Coagulation Male Gonad Development Protein Kinase A Signaling Activation Of Protein Kinase A Activity High-density Lipoprotein Particle Assembly Cellular Response To Glucagon Stimulus	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Regulation Of Cell Cycle
Pathways		PKA-mediated phosphorylation of CREB PKA-mediated phosphorylation of key metabolic factors Triglyceride catabolism PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins VEGFA-VEGFR2 Pathway CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of Adenylate Cyclase Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state CD209 (DC-SIGN) signaling MAPK6/MAPK4 signaling RET signaling HDL assembly ROBO receptors bind AKAP5 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs			Fostamatinib
Diseases
GWAS		Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)	Diastolic blood pressure ( 30224653) Manganese levels ( 26025379) Phospholipid levels (plasma) ( 22359512)
Interacting Genes		5 interacting genes: CDK17 CETP HMGN1 TNP1 TNP2	12 interacting genes: APP BICDL2 CDKN2B DPY30 EPHA2 PRKACG TDRD7 TGFBR1 UBC YWHAG YWHAQ YWHAZ
Entrez ID		5568	5128
HPRD ID		01483	09141
Ensembl ID		ENSG00000165059	ENSG00000059758
Uniprot IDs		P22612	A0A024RBH0 Q00537
PDB IDs
Enriched GO Terms of Interacting Partners?
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