PNRC2 and NR5A2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PNRC2	NR5A2
Description		proline rich nuclear receptor coactivator 2	nuclear receptor subfamily 5 group A member 2
Image
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Golgi Apparatus Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-independent Decapping Of Nuclear-transcribed MRNA	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Bile Acid Metabolic Process Hormone-mediated Signaling Pathway Embryo Development Ending In Birth Or Egg Hatching Tissue Development Intracellular Receptor Signaling Pathway Epithelial Cell Differentiation Regulation Of Cell Population Proliferation Homeostatic Process Cholesterol Homeostasis Positive Regulation Of Viral Genome Replication Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Pancreas Morphogenesis Calcineurin-mediated Signaling Cellular Response To Leukemia Inhibitory Factor
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Age at voice drop ( 27182965) Cerebrospinal T-tau levels ( 28247064) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) FEV1 ( 30804560) Gamma glutamyl transferase levels ( 29403010) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hepcidin/transferrin saturation ratio ( 27846281) Hyperinsulinemia in obesity ( 30327367) Hyperinsulinemia x BMI interaction ( 30327367) Inflammatory bowel disease ( 28067908) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Length of menstrual cycle ( 30202859) Lung adenocarcinoma ( 28604730) Lung function (FVC) ( 30061609 30804560) Menarche (age at onset) ( 25231870) Myopia ( 27182965) Nicotine dependence ( 28440896) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Pancreatic cancer ( 29422604 20101243 27579533 26098869 25086665) Refractive error ( 32231278) Rheumatoid arthritis ( 25014791) Ulcerative colitis ( 28067908) Uric acid levels ( 21294900) Urinary albumin excretion ( 30220432)
Interacting Genes		23 interacting genes: APP AR BANP DCP1A ESR1 ESR2 ESRRA ESRRG FBXO7 GALK1 GLOD4 HNF4A HNF4G NR5A1 NR5A2 RARA RARG RORA RORB SPAG9 XRCC6 ZBTB16 ZBTB48	21 interacting genes: ALB BCKDK DDB2 EDF1 FTH1 GTF2H2C NCOA1 NCOA3 NPPA NR0B2 NR1I2 NRIP1 NSD1 PNRC1 PNRC2 POLR2D PROX1 RAD54L2 SMARCD3 SREBF1 UBE2I
Entrez ID		55629	2494
HPRD ID		17871	06830
Ensembl ID		ENSG00000189266	ENSG00000116833
Uniprot IDs		Q9NPJ4	F1D8R9 O00482
PDB IDs		4B6H 5KQ1 5KQ4	1YOK 1YUC 1ZDU 2A66 3PLZ 3TX7 4DOR 4DOS 4IS8 4ONI 4PLD 4PLE 4RWV 5L0M 5L11 5SYZ 5UNJ 6OQX 6OQY 6OR1 6VIF
Enriched GO Terms of Interacting Partners?
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