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STAP2 and PTK6
Data Source:
HPRD
(two hybrid)
STAP2
PTK6
Description
signal transducing adaptor family member 2
protein tyrosine kinase 6
Image
GO Annotations
Cellular Component
Cytosol
Plasma Membrane
Ruffle
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Nuclear Body
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Molecular Function
Protein Binding
Signaling Adaptor Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Identical Protein Binding
Biological Process
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Signal Transduction
Positive Regulation Of Neuron Projection Development
Cell Migration
Cell Differentiation
ERBB2 Signaling Pathway
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Innate Immune Response
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cell Cycle
Negative Regulation Of Growth
Protein Autophosphorylation
Intestinal Epithelial Cell Differentiation
Negative Regulation Of Protein Tyrosine Kinase Activity
Cellular Response To Retinoic Acid
Pathways
PTK6 Activates STAT3
SCF(Skp2)-mediated degradation of p27/p21
Cyclin D associated events in G1
ERBB2 Activates PTK6 Signaling
PTK6 Regulates Proteins Involved in RNA Processing
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
PTK6 Regulates Cell Cycle
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
PTK6 Down-Regulation
PTK6 Expression
PTK6 Activates STAT3
PTK6 promotes HIF1A stabilization
Drugs
Vandetanib
Fostamatinib
Zanubrutinib
Diseases
GWAS
Tea consumption (
31046077
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Hair shape (
29220522
)
Prostate cancer (
23535732
)
Interacting Genes
18 interacting genes:
BLK
BMP4
CBL
CHUK
CSF1R
EGFR
IKBKB
JAK2
KEAP1
MLH1
MYD88
PTK6
SRC
STAT3
STAT5A
STAT5B
TXK
YES1
35 interacting genes:
ACTN3
ANKRD55
APP
AR
CBLB
CCDC33
DDX17
DOK1
DTX3
EFHC2
EGFR
ERBB2
ERBB3
ERBB4
EXOC5
FCHO1
FGFR1
GAB1
HIF1A
KHDRBS1
KHDRBS2
KIAA1217
KIT
LINC01139
MEIS2
MET
MKRN3
MYOZ3
PITX1
PRDM6
REL
SLA
STAP2
WASL
ZNF341
Entrez ID
55620
5753
HPRD ID
07430
03594
Ensembl ID
ENSG00000178078
ENSG00000101213
Uniprot IDs
Q9UGK3
Q13882
PDB IDs
2EL8
1RJA
2KGT
5D7V
5DA3
5H2U
6CZ2
6CZ3
6CZ4
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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